{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T06:41:52Z","timestamp":1783406512019,"version":"3.54.6"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T00:00:00Z","timestamp":1705968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009429","name":"Caisse Centrale de la Mutualit\u00e9 Sociale Agricole","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009429","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2024,4]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Chronic infectious diseases are increasingly being considered as potential contributors to dementia risk. Among those infections,\n Helicobacter pylori<\/jats:italic>\n , the main cause of chronic gastritis worldwide, has been suggested. As the prevalence of\n H. pylori<\/jats:italic>\n infection has decreased, the main objective of this work was to reconsider the association between\n H. pylori<\/jats:italic>\n infection and the risk of incident dementia, including Alzheimer's disease.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Prospective cohort of 689 older (\u226565\u2009years) agricultural workers from Southwest France. Descriptive and comparative analyses were performed according to\n H. pylori<\/jats:italic>\n status determined by serology at baseline. The risk of incident dementia according to\n H. pylori<\/jats:italic>\n status over a 7\u2010year follow\u2010up was explored by survival analyses: Kaplan\u2013Meier curve and Cox proportional hazards models.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Two\u2010hundred (29.0%) participants were\n H. pylori<\/jats:italic>\n \u2010positive at baseline. Compared to\n H. pylori<\/jats:italic>\n \u2010negative participants, they showed worse cognitive performances at baseline. Eighty\u2010five incident dementia cases were diagnosed during the follow\u2010up period. After adjustment for age, sex, education, apolipoprotein \u03b54, and several cardiovascular risk factors,\n H. pylori<\/jats:italic>\n remained associated with an increased risk of dementia (HR 1.70, 95% CI, 1.05\u20132.74). The risk was stronger for Alzheimer's disease (HR 2.85, 95% CI, 1.58\u20135.12).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Despite an observed decrease in\n H. pylori<\/jats:italic>\n infection prevalence, this study provides evidence for the association between\n H. pylori<\/jats:italic>\n infection and dementia. These results should encourage further research on the mechanisms underlying the contribution of infectious diseases to pathological brain aging, especially the influence of gut inflammation on the brain.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgs.18748","type":"journal-article","created":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T04:05:21Z","timestamp":1705982721000},"page":"1191-1198","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Association between\n \n Helicobacter pylori<\/i>\n <\/scp>\n infection and incident risk of dementia: The\n AMI<\/scp>\n cohort"],"prefix":"10.1111","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4163-5278","authenticated-orcid":false,"given":"Virgilio","family":"Hern\u00e1ndez\u2010Ruiz","sequence":"first","affiliation":[{"name":"INSERM, Bordeaux Population Health Research Center, UMR 1219 University of Bordeaux Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Roubaud\u2010Baudron","sequence":"additional","affiliation":[{"name":"P\u00f4le de G\u00e9rontologie Clinique CHU Bordeaux Bordeaux France"},{"name":"INSERM, UMR U1312 \u2010 BRIC University of Bordeaux Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Von Campe","sequence":"additional","affiliation":[{"name":"INSERM, Bordeaux Population Health Research Center, UMR 1219 University of Bordeaux Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noelia","family":"Retuerto","sequence":"additional","affiliation":[{"name":"INSERM, Bordeaux Population Health Research Center, UMR 1219 University of Bordeaux Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"M\u00e9graud","sequence":"additional","affiliation":[{"name":"INSERM, UMR U1312 \u2010 BRIC University of Bordeaux Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Helmer","sequence":"additional","affiliation":[{"name":"INSERM, Bordeaux Population Health Research Center, UMR 1219 University of Bordeaux Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Amieva","sequence":"additional","affiliation":[{"name":"INSERM, Bordeaux Population Health Research Center, UMR 1219 University of Bordeaux Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0720-0684","authenticated-orcid":false,"given":"Karine","family":"P\u00e9r\u00e8s","sequence":"additional","affiliation":[{"name":"INSERM, Bordeaux Population Health Research Center, UMR 1219 University of Bordeaux Bordeaux 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