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SDoH measures included race, the national\u2010rank area deprivation index, education, and income. We examined associations of late\u2010life gait speed with midlife hsCRP (V2 continuous and clinically high \u22653\u2009mg\/L), with 20\u2010year hsCRP history from midlife (V2\u2013V5 average continuous hsCRP and clinically high \u22653\u2009mg\/L) and with inflammation accumulation (visits and years with high hsCRP). Regression models adjusted for demographic, cardiovascular, and SDoH measures; effect modification by the presence of other common chronic conditions (obesity, diabetes, hypertension) and race were examined, with and without accounting for SDoH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>High midlife hsCRP was associated with slower late\u2010life gait speed, even among those without chronic conditions in midlife: \u22124.6\u2009cm\/s (95% CI: \u22126.4, \u22122.8). Importantly, sustained high hsCRP was associated with a 20\u2010year slowing of \u221210.0\u2009cm\/s (\u221214.9, \u22125.1) among those who never experienced obesity, diabetes, or hypertension over the 20\u2010year period. Associations were similar between Black participants, \u22123.8\u2009cm\/s (\u22126.9, \u22120.7) and White participants \u22123.3 (\u22124.5, \u22122.2) per interquartile range of midlife hsCRP; effect modifications by chronic conditions and race were unsupported throughout. Results were robust to accounting for SDoH or otherwise; however, worse SDoH was associated with higher inflammation and slower gait speed in both Black and White participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Inflammation in midlife may contribute to clinically meaningful late\u2010life slowing of gait speed, even among otherwise healthy\u2010appearing adults and regardless of race and socioeconomic disadvantage. Regular monitoring and interventions for inflammation may be warranted from midlife.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.18978","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T03:01:15Z","timestamp":1718161275000},"page":"2434-2445","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Associations of mid\u2010to\u2010late\u2010life inflammation with late\u2010life mobility and the influences of chronic comorbidities, race, and social determinants of health: The Atherosclerosis Risk in Communities Study"],"prefix":"10.1111","volume":"72","author":[{"given":"Kirby G.","family":"Parker","sequence":"first","affiliation":[{"name":"Department of Radiology University of Mississippi Medical Center  Jackson Mississippi USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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