{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T05:23:51Z","timestamp":1785821031556,"version":"3.56.0"},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Age\u2010related changes in the gastrointestinal system are common and may be influenced by physiological aging processes. To date, a comprehensive analysis of esophageal motor disorders in patients belonging to various age groups has not been adequately reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective assessment of high\u2010resolution manometry (HRM) studies in a multicenter setting. HRM parameters were evaluated according to the Chicago Classification version 4.0. Epidemiological, demographic, clinical data, and main manometric parameters, were collected at the time of the examination. Age groups were categorized as early adulthood (&lt;35\u2009years), early middle\u2010age (35\u201349\u2009years), late middle\u2010age (50\u201364\u2009years), and late adulthood (\u226565\u2009years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 1341 patients (632, 47.0% male) were included with a median age of 55\u2009years. Late adulthood patients reported more frequently dysphagia (35.2%) than early adulthood patients (24.0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.035), early middle\u2010age patients (21.0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), and late middle\u2010aged patients (22.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Esophagogastric junction outflow obstruction was more prevalent in late adulthood (16.7%) than in early adulthood (6.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003), and in early middle\u2010age (8.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). Patients with normal esophageal motility were significantly younger (52.0\u2009years) than patients with hypercontractile esophagus (61.5\u2009years), type III achalasia (59.6\u2009years), esophagogastric junction outflow obstruction (59.4\u2009years), absent contractility (57.2\u2009years), and distal esophageal spasm (57.0\u2009years), in multivariate model (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The rate of esophageal motor disorders is higher in older patients, in particular esophagogastric junction outflow obstruction and hypercontractile esophagus. Future prospective studies are necessary to confirm our results and to find tailored strategies to improve clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.19068","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T09:49:18Z","timestamp":1720432158000},"page":"2782-2791","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Esophageal motor disorders across ages: A retrospective multicentric analysis"],"prefix":"10.1111","volume":"72","author":[{"given":"Andrea","family":"Pasta","sequence":"first","affiliation":[{"name":"Gastroenterology Unit, Department of Internal Medicine University of Genoa  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Facchini","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Internal Medicine University of Genoa  Genoa 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