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We characterized the frequency and types of high\u2010risk medications used by older adults with CI living alone and, for context, compared patterns with those in older adults with CI living with others.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a cross\u2010sectional study of National Health and Aging Trends Study (NHATS) data and Medicare claims (2015\u20132017). We ascertained cognitive status from NHATS and medication use with Part D claims. We compared high\u2010risk medication use (those with adverse cognitive effects or low tolerance for misuse) among older adults with CI living alone versus living with others using logistic regression models adjusted for demographic\/clinical factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The unweighted sample included 1569 older adults with CI, of whom 491 (weighted national estimate, 31%) were living alone. In the living\u2010alone group, the mean age was 79.9\u2009years and 66% were female, 64% reported managing medications on their own without difficulty, 14% reported managing medications on their own with difficulty, and 18% received total support with medication management. Older adults with CI living alone used a median of 5 medications (IQR, 3\u20138), 16% took \u226510 medications, and 46% took \u22651 high\u2010risk medication (anticholinergic\/sedating: 24%; opioid: 13%; anticoagulant: 10%; sulfonylurea: 10%; insulin: 9%). Compared with those living with others, the use of high\u2010risk medications was similar (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05 for unadjusted\/adjusted comparisons). Those living alone were more likely both to take at least one high\u2010risk medication and not receive help with medication management: 34% in those living alone versus 23% living with others (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05 for unadjusted\/adjusted comparisons).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Older adults with CI living alone use many medications; nearly half use high\u2010risk medications. Our findings can inform medication optimization interventions supporting this vulnerable population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.19108","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T07:49:05Z","timestamp":1721980145000},"page":"3719-3729","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["High\u2010risk medication use among older adults with cognitive impairment living alone in the United States"],"prefix":"10.1111","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5997-4406","authenticated-orcid":false,"given":"Matthew E.","family":"Growdon","sequence":"first","affiliation":[{"name":"Division of Geriatrics, Department of Medicine University of California  San Francisco California USA"},{"name":"San Francisco VA Medical Center  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bocheng","family":"Jing","sequence":"additional","affiliation":[{"name":"Division of Geriatrics, Department of Medicine University of California  San Francisco California USA"},{"name":"San Francisco VA Medical Center  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Yaffe","sequence":"additional","affiliation":[{"name":"San Francisco VA Medical Center  San Francisco California USA"},{"name":"Department of Epidemiology and Biostatistics University of California  San Francisco California USA"},{"name":"Department of Psychiatry University of California  San Francisco California USA"},{"name":"Department of Neurology, Memory and Aging Center University of California  San Francisco California USA"},{"name":"The Global Brain Health Institute University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah S.","family":"Karliner","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Department of Medicine University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine L.","family":"Possin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Memory and Aging Center University of California  San Francisco California USA"},{"name":"The Global Brain Health Institute University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2311-3836","authenticated-orcid":false,"given":"Elena","family":"Portacolone","sequence":"additional","affiliation":[{"name":"Institute for Health &amp; Aging University of California  San Francisco California USA"},{"name":"Philip R. Lee Institute for Health Policy Studies University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. John","family":"Boscardin","sequence":"additional","affiliation":[{"name":"Division of Geriatrics, Department of Medicine University of California  San Francisco California USA"},{"name":"San Francisco VA Medical Center  San Francisco California USA"},{"name":"Department of Epidemiology and Biostatistics University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5373-3011","authenticated-orcid":false,"given":"Krista L.","family":"Harrison","sequence":"additional","affiliation":[{"name":"Division of Geriatrics, Department of Medicine University of California  San Francisco California USA"},{"name":"The Global Brain Health Institute University of California  San Francisco California USA"},{"name":"Philip R. 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