{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:52:08Z","timestamp":1791219128528,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:00:00Z","timestamp":1725840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2024,11]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Current guidelines for the diagnosis and treatment of pericarditis refer to the general adult population. Few and fragmentary data regarding recurrent pericarditis in older adults exist.<\/jats:p>\n <\/jats:sec>\n \n Objective of the Study<\/jats:title>\n Given the absence of specific data in scientific literature, we hypothesized that there might be clinical, laboratory and outcome differences between young adults and older adults affected by idiopathic recurrent pericarditis.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n We performed an international multicentric retrospective cohort study analyzing data from patients affected by recurrent pericarditis (idiopathic or post\u2010cardiac injury) and referring to tertiary referral centers. Clinical, laboratory, and outcome data were compared between patients younger than 65\u2009years (controls) and patients aged 65 or older.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n One hundred and thirty\u2010three older adults and 142 young adult controls were enrolled. Comorbidities, including chronic kidney diseases, atrial fibrillation, and diabetes, were more present in older adults. The presenting symptom was dyspnea in 54.1% of the older adults versus 10.6% in controls (\n p<\/jats:italic>\n \u2009<\u20090.001); pain in 32.3% of the older adults versus 80.3% of the controls (\n p<\/jats:italic>\n \u2009<\u20090.001). Fever higher than 38\u00b0C was present in 33.8% versus 53.5% (\n p<\/jats:italic>\n \u2009=\u20090.001). Pleural effusion was more prevalent in the older adults (55.6% vs 34.5%,\n p<\/jats:italic>\n \u2009<\u20090.001), as well as severe pericardial effusion (>20\u2009mm) (24.1% vs 12.7%,\n p<\/jats:italic>\n \u2009=\u20090.016) and pericardiocentesis (16.5% vs 8.5%,\n p<\/jats:italic>\n \u2009=\u20090.042). Blood leukocyte counts were significantly lower in the older adults (mean\u2009+\u2009SE: 10,227\u2009+\u2009289\/mm\n 3<\/jats:sup>\n vs 11,208\u2009+\u2009285\/mm\n 3<\/jats:sup>\n ,\n p<\/jats:italic>\n \u2009=\u20090.016). Concerning therapies, NSAIDS were used in 63.9% of the older adults versus 80.3% in the younger (\n p<\/jats:italic>\n \u2009=\u20090.003), colchicine in 76.7% versus 87.3% (\n p<\/jats:italic>\n \u2009=\u20090.023), corticosteroids in 49.6% versus 26.8% (\n p<\/jats:italic>\n \u2009<\u20090.001), and anakinra in 14.3% versus 23.9% (\n p<\/jats:italic>\n \u2009=\u20090.044).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Older adults affected by recurrent pericarditis show a different clinical pattern, with more frequent dyspnea, pleural effusion, severe pericardial effusion, and lower fever and lower leukocyte count, making the diagnosis sometimes challenging. They received significantly less NSAIDs and colchicine, likely due to comorbidities; they were also treated less commonly with anti\u2010IL1 agents, and more frequently with corticosteroids.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgs.19150","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T05:11:01Z","timestamp":1725858661000},"page":"3467-3475","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Recurrent pericarditis in older adults: Clinical and laboratory features and outcome"],"prefix":"10.1111","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8560-5866","authenticated-orcid":false,"given":"Emanuele","family":"Bizzi","sequence":"first","affiliation":[{"name":"Internal Medicine Department Fatebenefratelli and Sacco Hospitals Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3635-8235","authenticated-orcid":false,"given":"Francesco","family":"Cavaleri","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Fatebenefratelli and Sacco Hospitals Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7156-5517","authenticated-orcid":false,"given":"Ruggiero","family":"Mascolo","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Fatebenefratelli and Sacco Hospitals Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1443-5788","authenticated-orcid":false,"given":"Edoardo","family":"Conte","sequence":"additional","affiliation":[{"name":"Clinical Cardiology and Cardiovascular Imaging Unit Galeazzi\u2010Sant'Ambrogio Hospital IRCCS Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2482-2717","authenticated-orcid":false,"given":"Stefano","family":"Maggiolini","sequence":"additional","affiliation":[{"name":"Cardiology Division, Cardiovascular Department San L. Mandic Hospital Merate (Lc) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2582-6672","authenticated-orcid":false,"given":"Caterina Chiara","family":"Decarlini","sequence":"additional","affiliation":[{"name":"Cardiology Division, Cardiovascular Department San L. Mandic Hospital Merate (Lc) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9398-8366","authenticated-orcid":false,"given":"Silvia","family":"Maestroni","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Papa Giovanni XXIII Hospital Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0008-4630","authenticated-orcid":false,"given":"Valentino","family":"Collini","sequence":"additional","affiliation":[{"name":"Department of Medicine (DMED) University of Udine Udine Italy"},{"name":"Cardiothoracic Department University Hospital Santa Maria della Misericordia Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4713-0382","authenticated-orcid":false,"given":"Ludovico Luca","family":"Sicignano","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario \u201cA. Gemelli\u201d IRCCS Rome Italy"},{"name":"Department of Geriatrics and Orthopedics Universit\u00e0 Cattolica del Sacro Cuore Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2131-2110","authenticated-orcid":false,"given":"Elena","family":"Verrecchia","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario \u201cA. Gemelli\u201d IRCCS Rome Italy"},{"name":"Department of Geriatrics and Orthopedics Universit\u00e0 Cattolica del Sacro Cuore Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1560-3907","authenticated-orcid":false,"given":"Raffaele","family":"Manna","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario \u201cA. Gemelli\u201d IRCCS Rome Italy"},{"name":"Department of Geriatrics and Orthopedics Universit\u00e0 Cattolica del Sacro Cuore Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Pancrazi","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Fatebenefratelli and Sacco Hospitals Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4130-5519","authenticated-orcid":false,"given":"Lucia","family":"Trotta","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Fatebenefratelli and Sacco Hospitals Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4524-9566","authenticated-orcid":false,"given":"Giuseppe","family":"Lopalco","sequence":"additional","affiliation":[{"name":"Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe\u2010J) University of Bari Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1053-5178","authenticated-orcid":false,"given":"Danilo","family":"Malandrino","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgery and Health Sciences, University of Trieste, and Clinical Medicine and Rheumatology Unit Cattinara University Hospital Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6294-7932","authenticated-orcid":false,"given":"Giada","family":"Pallini","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Fatebenefratelli and Sacco Hospitals Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4609-8458","authenticated-orcid":false,"given":"Sara","family":"Catenazzi","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Fatebenefratelli and Sacco Hospitals Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8939-1513","authenticated-orcid":false,"given":"Luisa","family":"Carrozzo","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Fatebenefratelli and Sacco Hospitals Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9575-8321","authenticated-orcid":false,"given":"Giacomo","family":"Emmi","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgery and Health Sciences, University of Trieste, and Clinical Medicine and Rheumatology Unit Cattinara University Hospital Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2802-9617","authenticated-orcid":false,"given":"George","family":"Lazaros","sequence":"additional","affiliation":[{"name":"First Cardiology Department, School of Medicine, Hippokration General Hospital National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-5600","authenticated-orcid":false,"given":"Antonio","family":"Brucato","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Fatebenefratelli and Sacco Hospitals Milan Italy"},{"name":"Department of Biomedical and Clinical Sciences \u201cLuigi Sacco,\u201d University of Milan Luigi Sacco Hospital Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5722-0245","authenticated-orcid":false,"given":"Massimo","family":"Imazio","sequence":"additional","affiliation":[{"name":"Department of Medicine (DMED) University of Udine Udine Italy"},{"name":"Cardiothoracic Department University Hospital Santa Maria della Misericordia Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,9]]},"reference":[{"issue":"12","key":"e_1_2_10_2_1","first-page":"1126","article-title":"2015 ESC guidelines for the diagnosis and management of pericardial diseases","volume":"68","author":"Adler Y","year":"2015","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.89520"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-023-00946-3"},{"issue":"11","key":"e_1_2_10_5_1","first-page":"2131","article-title":"Autoinflammatory recurrent pericarditis associated with a new NLRP12 mutation in a male adolescent","volume":"13","author":"Cinteza E","year":"2023","journal-title":"Life (Basel)"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2023.05.011"},{"issue":"1","key":"e_1_2_10_7_1","first-page":"79","article-title":"P\u00e9ricardites 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of the American Geriatrics 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