{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:57:14Z","timestamp":1790215034392,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T00:00:00Z","timestamp":1726272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG005394"],"award-info":[{"award-number":["R01 AG005394"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG005407"],"award-info":[{"award-number":["R01 AG005407"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG027574"],"award-info":[{"award-number":["R01 AG027574"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG027576"],"award-info":[{"award-number":["R01 AG027576"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AR35582"],"award-info":[{"award-number":["R01 AR35582"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AR35583"],"award-info":[{"award-number":["R01 AR35583"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AR35584"],"award-info":[{"award-number":["R01 AR35584"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Life\u2010space mobility captures the daily, enacted mobility of older adults. We determined cross\u2010sectional associations between life\u2010space mobility and cognitive impairment (CI) among community\u2010dwelling women in the 9th and 10th decades of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 1375 (mean age 88\u2009years; 88% White) community\u2010dwelling women enrolled in a prospective cohort of older women. Life\u2010space score was calculated with range 0 (daily restriction to one's bedroom) to 120 (daily trips leaving town without assistance) and categorized (0\u201320, 21\u201340, 41\u201360, 61\u201380, 81\u2013120). The primary outcome was adjudicated CI defined as mild cognitive impairment or dementia; scores on a 6\u2010test cognitive battery were secondary outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared to women with life\u2010space scores of 81\u2013120 and after adjustment for demographics and depressive symptoms, the odds of CI was 1.4\u2010fold (OR 1.36, 95% CI 0.91\u20132.03) higher for women with life\u2010space scores of 61\u201380, twofold (OR 1.98, 95% CI 1.33\u20132.94) higher for women with life\u2010space scores of 41\u201360, 2.6\u2010fold (OR 2.62, 95% CI 1.71\u20134.01) higher for women with life\u2010space scores of 21\u201340, and 2.7\u2010fold (OR 2.71, 95% CI 1.27\u20135.79) higher for women with life\u2010space scores of 0\u201320. The association of life\u2010space scores with adjudicated CI was primarily due to higher odds of dementia; the odds of dementia versus normal cognition was eightfold (OR 8.63, 95% CI 3.20\u201323.26) higher among women with life\u2010space scores of 0\u201320 compared to women with life\u2010space scores of 81\u2013120. Lower life\u2010space scores were associated in a graded manner with lower mean scores on tests of delayed recall (California Verbal Learning Test\u2010II delayed recall) and language and executive function (phonemic fluency, category fluency, and Trails B). Life\u2010space score was not associated with scores on tests of attention and working memory (forward and backward digit span).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Lower life\u2010space mobility is associated in a graded manner with CI among community\u2010dwelling White women in the 9th and 10th decades of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.19190","type":"journal-article","created":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T04:35:28Z","timestamp":1726288528000},"page":"206-213","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Life\u2010space mobility and cognition in community\u2010dwelling late\u2010life women: A cross\u2010sectional analysis"],"prefix":"10.1111","volume":"73","author":[{"given":"Kerry M.","family":"Sheets","sequence":"first","affiliation":[{"name":"Geriatric Medicine Division, Department of Medicine Hennepin Healthcare  Minneapolis Minnesota USA"},{"name":"Department of Medicine University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allyson M.","family":"Kats","sequence":"additional","affiliation":[{"name":"Division of Epidemiology &amp; Community Health, School of Public Health University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard A.","family":"Fink","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Minnesota  Minneapolis Minnesota USA"},{"name":"Division of Epidemiology &amp; Community Health, School of Public Health University of Minnesota  Minneapolis Minnesota USA"},{"name":"Center for Care Delivery and Outcomes Research VA Health Care System  Minneapolis Minnesota USA"},{"name":"Geriatric Research Education and Clinical Center VA Health Care System  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Langsetmo","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Minnesota  Minneapolis Minnesota USA"},{"name":"Division of Epidemiology &amp; Community Health, School of Public Health University of Minnesota  Minneapolis Minnesota USA"},{"name":"Center for Care Delivery and Outcomes Research VA Health Care System  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Yaffe","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Neurology, and Epidemiology &amp; Biostatistics University of California, San Francisco  San Francisco California USA"},{"name":"San Francisco Veterans Affairs Health Care System  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9069-3036","authenticated-orcid":false,"given":"Kristine E.","family":"Ensrud","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Minnesota  Minneapolis Minnesota USA"},{"name":"Division of Epidemiology &amp; Community Health, School of Public Health University of Minnesota  Minneapolis Minnesota USA"},{"name":"Center for Care Delivery and Outcomes Research VA Health Care System  Minneapolis Minnesota 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