{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T08:13:25Z","timestamp":1780992805716,"version":"3.54.1"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Motor signs may herald incident dementia and allow the earlier detection of high\u2010risk individuals and the timely implementation of preventive interventions. The current study was performed to investigate the prognostic properties of motor signs with respect to incident dementia with Lewy bodies (DLB) in older adults with mild cognitive impairment (MCI). Emphasis was placed on sex differences. The specificity of these associations was explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed data from the National Alzheimer's Coordinating Center Uniform Data Set. Participants 55\u2009+\u2009years old with a diagnosis of MCI were included in the analysis. Those with Parkinson's disease (PD) or other parkinsonian disorders at baseline and those with PD dementia at follow\u2010up were excluded. UPDRS III was used to assess the presence or absence of motor signs in nine domains: hypophonia; masked facies; resting tremor; action\/postural tremor; rigidity; bradykinesia; impaired chair rise; impaired posture\/gait; postural instability. \u0391djusted Cox proportional hazards models featuring sex by motor sign interactions were estimated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Throughout the average follow\u2010up of 3.7\u2009\u00b1\u20093.1\u2009years, among 4623 individuals with MCI, 2211 progressed to dementia (66 of whom converted to DLB). Masked facies [HR\u2009=\u20094.21 (1.74\u201310.18)], resting tremor [HR\u2009=\u20094.71 (1.44\u201315.40)], and bradykinesia [HR\u2009=\u20093.43 (1.82\u20136.45)] exclusively increased the risk of DLB. The HR of DLB was approximately 15 times greater in women compared to men with masked facies. Impaired posture\u2013gait (approximately 10 times) and resting tremor (approximately 8.5 times) exhibited a similar trend (prominent risk\u2010conferring properties in women compared to men) but failed to achieve statistical significance. Rigidity and hypophonia elevated the risk of other dementia entities, as well. The remaining motor features were not related to incident dementia of any type.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Specific motor signs may herald DLB among individuals with MCI. Different associations may exist between masked facies, impaired posture\u2013gait, resting tremor, and incident DLB in men versus women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.19238","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T08:33:34Z","timestamp":1730795614000},"page":"50-62","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Motor signs and incident dementia with Lewy bodies in older adults with mild cognitive impairment"],"prefix":"10.1111","volume":"73","author":[{"given":"Ioannis","family":"Liampas","sequence":"first","affiliation":[{"name":"Department of Neurology, University Hospital of Larissa, School of Medicine University of Thessaly  Larissa Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasileios","family":"Siokas","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of 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