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Multimorbidity was operationalized as the number of chronic conditions and multimorbidity patterns identified using latent class analysis (LCA). Joint models and Cox regression models were used to explore the associations between multimorbidity, and subsequent absolute and relative (\u226525% decline from baseline) changes, respectively, in the estimated glomerular filtration rate (eGFR) calculated using the creatinine\u2010based Berlin Initiative Study equation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean age of the sample was 73.9, and 87% had multimorbidity. There was an independent dose\u2013response relationship between the number of chronic conditions, and absolute (\u03b2 [95% confidence interval, CI]\u2009=\u2009\u22120.05 [\u22120.07; \u22120.03]) and relative (hazard ratio, HR [95% CI]\u2009=\u20091.23 [1.17; 1.29]) declines in eGFR. Five patterns of multimorbidity were identified. The\n                      <jats:italic>Unspecific, low burden<\/jats:italic>\n                      pattern had the lowest morbidity burden and was used as the reference category. The\n                      <jats:italic>Unspecific, high burden<\/jats:italic>\n                      , and\n                      <jats:italic>Cardiometabolic<\/jats:italic>\n                      patterns showed accelerated absolute (\u03b2 [95% CI]\u2009=\u2009\u22120.15 [\u22120.26; \u22120.05] and \u22120.77 [\u22120.98; \u22120.55], respectively) and relative (HR [95% CI]\u2009=\u20091.45 [1.09; 1.92] and 3.45 [2.27; 5.23], respectively) declines. Additionally, the\n                      <jats:italic>Cognitive and Sensory<\/jats:italic>\n                      pattern showed accelerated relative decline (HR [95% CI]\u2009=\u20091.53 [1.02; 2.31]). No associations were found for the\n                      <jats:italic>Psychiatric and Respiratory<\/jats:italic>\n                      pattern.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Multimorbidity is strongly associated with accelerated kidney function decline in older age. Individuals with cardiometabolic multimorbidity exhibit a particularly increased risk. Increased monitoring and timely interventions may preserve kidney function and reduce cardiovascular risks in individuals presenting with conditions that are characteristic of high\u2010risk multimorbidity patterns.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.19298","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T02:01:22Z","timestamp":1734487282000},"page":"837-848","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Associations between multimorbidity and kidney function decline in old age: A population\u2010based cohort study"],"prefix":"10.1111","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2615-226X","authenticated-orcid":false,"given":"Giorgi","family":"Beridze","sequence":"first","affiliation":[{"name":"Aging Research Center, Department of Neurobiology, Care Sciences and Society Karolinska Institutet and Stockholm University  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