{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T14:59:05Z","timestamp":1784991545246,"version":"3.55.0"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:00:00Z","timestamp":1733184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Data on patients aged 90 or older are rare. This study aims to describe clinical characteristics, treatment strategies, and clinical outcomes (rates of VTE recurrence, major bleeding, and mortality), during the first 3\u2009months of anticoagulant treatment for VTE, depending on the treatment period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed data from RIETE, an ongoing global observational registry of patients with objectively confirmed acute VTE, grouped in 5\u2010year intervals (2004\u20132008, 2009\u20132013, 2014\u20132018, and 2019\u20132023).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 3477 patients aged 90 or older, clinical characteristics have changed over time (less heart failure, more dementia), with an increase in PE diagnoses from 57% in 2004\u20132008 to 69% in 2019\u20132023 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2010trends &lt;0.001), but of lower severity. For long\u2010term therapy, there was an increase in patients receiving DOACs (\n                      <jats:italic>p<\/jats:italic>\n                      \u2010trends &lt;0.001), with a decrease in patients on VKAs (\n                      <jats:italic>p<\/jats:italic>\n                      \u2010trends &lt;0.001). Mortality and fatal PE respectively showed a temporal trend: 19% and 4% in 2004\u20132008 to 15% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2010trends 0.026) and 2% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2010trends 0.002) in 2019\u20132023. In multivariable analyses, fatal PE declined from 2004 to 2023 (HR: 0.91; 95% CI: 0.87\u20130.96). Compared with VKAs, receiving LMWH during the first 3\u2009months of anticoagulation was associated with a higher risk of major bleeding (HR: 1.91; 95% CI: 1.16\u20133.14) and death (HR: 2.20; 95% CI: 1.71\u20132.82). The effect seems to be the opposite for DOACs (HR: 0.50; 95% CI: 0.20\u20131.30 for major bleeding; HR: 0.86; 95% CI: 0.57\u20131.28 for all\u2010cause death).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Fatal PE declined from 2004 to 2023, despite an increase in the diagnosis of PE. Since the arrival of DOACs, there seems to be better management of the therapeutic and diagnostic aspects of VTE in this population, underlining the need for further research on patients aged 90 or older.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.19306","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T11:19:49Z","timestamp":1733224789000},"page":"1219-1226","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Venous thromboembolism in patients aged \u226590\u2009years: Trends in clinical features, treatment, and outcomes\u2014\n                    <scp>RIETE<\/scp>\n                    registry"],"prefix":"10.1111","volume":"73","author":[{"given":"Ludovic","family":"Lafaie","sequence":"first","affiliation":[{"name":"D\u00e9partement de G\u00e9rontologie Clinique CHU de Saint\u2010Etienne  Saint\u2010Etienne France"},{"name":"INSERM, UMR1059, Equipe Dysfonction Vasculaire et H\u00e9mostase Universit\u00e9 de Lyon  Saint\u2010Etienne France"},{"name":"F\u2010CRIN INNOVTE Network  Saint\u2010Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9raldine","family":"Poenou","sequence":"additional","affiliation":[{"name":"F\u2010CRIN INNOVTE Network  Saint\u2010Etienne France"},{"name":"Service de M\u00e9decine Vasculaire et Th\u00e9rapeutique CHU de Saint\u2010Etienne  Saint\u2010Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Hanon","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris Cit\u00e9, INSERM, UMRS 1144  Paris France"},{"name":"H\u00f4pital Broca, Service de G\u00e9rontologie, Assistance Publique \u2013 H\u00f4pitaux de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Ot\u00e1lora","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hospital Universitario Virgen de Arrixaca  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano L\u00f3pez","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hospital Universitario, Reina Sof\u00eda  C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aitor","family":"Ballaz","sequence":"additional","affiliation":[{"name":"Respiratory Department Hospital Galdakao  Galdakao Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Soler","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hospital Olot i Comarcal de la Garrotxa  Gerona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel Jes\u00fas N\u00fa\u00f1ez","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hospital Universitario de Pontevedra  Pontevedra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Bertoletti","sequence":"additional","affiliation":[{"name":"INSERM, UMR1059, Equipe Dysfonction Vasculaire et H\u00e9mostase Universit\u00e9 de Lyon  Saint\u2010Etienne France"},{"name":"F\u2010CRIN INNOVTE Network  Saint\u2010Etienne France"},{"name":"Service de M\u00e9decine Vasculaire et Th\u00e9rapeutique CHU de Saint\u2010Etienne  Saint\u2010Etienne France"},{"name":"INSERM CIC1408, CHU de Saint\u2010Etienne  Saint\u2010Priest\u2010en\u2010Jarez France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Monreal","sequence":"additional","affiliation":[{"name":"Chair of Thromboembolic Diseases Universidad Cat\u00f3lica de Murcia  Murcia Spain"},{"name":"CIBER Enfermedades Respiratorias (CIBERES)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the RIETE investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,3]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Population par \u00e2ge \u2212 Tableaux de l\u2019\u00e9conomie fran\u00e7aise|INSEE? 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