{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T02:47:23Z","timestamp":1775011643229,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,22]],"date-time":"2024-12-22T00:00:00Z","timestamp":1734825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01DA044167"],"award-info":[{"award-number":["R01DA044167"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Opioid na\u00efve older adults may be at risk of overdose after receiving an initial opioid prescription.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This population\u2010based cohort study from a linked dataset of patients in Oregon, linking all payer claims data to other administrative datasets, aimed to assess the prescription\u2010 and patient\u2010level characteristics associated with increased odds of opioid overdose after an initial opioid prescription. Included patients were \u226565\u2009years old and received an index pain\u2010formulation opioid prescription between 2016 and 2019. The primary outcome was an index nonfatal or fatal overdose within 6\u2010 or 12\u2010months following index prescription. Patient characteristics included age, sex, insurance plan, number of medical comorbidities, and presence of psychiatric comorbidities. Prescription characteristics included opioid type, duration of action, and days' supply. A logistic regression model was used to determine the association with opioid overdose.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were 223,799 individuals included for analysis (58.6% 65\u201374\u2009years old, 53.9% female). There were 183 fatal or nonfatal opioid overdoses in 6\u2009months and 232 in 12\u2009months following the index prescription. Adults aged \u226585\u2009years were less likely to experience an overdose versus those 65\u201374\u2009years (6\u2010month adjusted odds ratio (aOR) 0.35, [95% confidence interval, 0.20\u20130.59]; 12\u2010month aOR 0.38 [0.24\u20130.60]). Multiple factors were associated with increased odds, including dually enrolled in Medicare\/Medicaid compared to commercial insurance (6\u2010month aOR 5.99, [1.93\u201319.65]; 12\u2010month aOR 3.53, [1.58\u20137.90]), three or more comorbidities compared to none: (6\u2010month aOR 3.69, [1.91\u20138.13]; 12\u2010month aOR 4.24, [2.32\u20137.74]), history of depression: (6\u2010month aOR 1.94, [1.34\u20132.81]; 12\u2010month aOR 2.20, [1.60\u20133.04]), received long\u2010acting opioids (6\u2010month aOR 5.76, [1.56\u201321.22]; 12\u2010month aOR 4.0, [1.39\u201311.55]) compared to short\u2010acting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>For older adults, there is an association between opioid overdose risk and factors including patient insurance type, patient comorbidities, and receiving a long\u2010acting opioid prescription. Providers should be aware of the risks of opioids in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.19323","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T01:46:51Z","timestamp":1734918411000},"page":"1105-1114","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Individual and prescription level factors associated with overdose in opioid na\u00efve older people"],"prefix":"10.1111","volume":"73","author":[{"given":"Kacey","family":"Little","sequence":"first","affiliation":[{"name":"Division of Research and Evaluation Comagine Health  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanae","family":"El Ibrahimi","sequence":"additional","affiliation":[{"name":"Division of Research and Evaluation Comagine Health  Portland Oregon USA"},{"name":"School of Public Health, Department of Epidemiology and Biostatistics University of Nevada  Las Vegas Nevada USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiah","family":"Yoo","sequence":"additional","affiliation":[{"name":"Division of Research and Evaluation Comagine Health  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Flores","sequence":"additional","affiliation":[{"name":"Division of Research and Evaluation Comagine Health  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Hendricks","sequence":"additional","affiliation":[{"name":"General Medical Sciences Division Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christi","family":"Hildebran","sequence":"additional","affiliation":[{"name":"Division of Research and Evaluation Comagine Health  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grant","family":"Ritter","sequence":"additional","affiliation":[{"name":"Schneider Institutes for Health Policy, Heller School for Social Policy and Management Brandeis University  Waltham Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dagan","family":"Wright","sequence":"additional","affiliation":[{"name":"Injury and Violence Prevention Program\u2014Public Health Division Oregon Health Authority  Oregon Portland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan","family":"Loy","sequence":"additional","affiliation":[{"name":"Injury and Violence Prevention Program\u2014Public Health Division Oregon Health Authority  Oregon Portland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4672-5184","authenticated-orcid":false,"given":"Scott G.","family":"Weiner","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,22]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Statistical Brief (Medical Expenditure Panel Survey (US))","author":"Moriya AS","year":"2023"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6911a5"},{"key":"e_1_2_10_4_1","unstructured":"U.S. Department of Health and Human Services O. o. 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