{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:10:45Z","timestamp":1791357045574,"version":"4.3.1"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In older people, medications with anticholinergic or sedative properties are associated with falls, frailty, and functional and cognitive impairment. These medications are often described as a subset of potentially inappropriate medications (PIMs). We examined the prevalence of anticholinergic or sedative medications to avoid in older people in France in 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional study used anonymized data from a large electronic healthcare database, the French National Health Data System (Syst\u00e8me National des Donn\u00e9es de Sant\u00e9, SNDS). All people aged 65\u2009years or older from January 1, 2023, to December 31, 2023, were included in this study. Dispensations of anticholinergic and sedative medications were identified according to PIM criteria (2023 American Geriatrics Society Beers Criteria and REMEDI[e]S tool). The prevalence of anticholinergic or sedative medications was assessed for the study population and by age (65\u201384 and 85 or older) and living place (home and institutionalized patients) subgroups in terms of number and percentage of patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This study included 16,938,152 patients aged 65\u2009years or older (55% women). Among all patients, 79.8% were aged between 65 and 84\u2009years and 20.2% were aged 85\u2009years or older. Most patients lived at home (97.0%), and 3.0% were institutionalized. The prevalence of anticholinergic or sedative medications was 32.8% among all patients, 32.3% among 65\u201384 patients, and 34.8% among 85 or older patients, 32.1% among home patients, and 54.5% among institutionalized patients. The most commonly dispensed anticholinergic or sedative medications were oxazepam (5.27%), alprazolam (5.27%), zopiclone (4.85%), bromazepam (4.23%), metopimazine (2.88%), paroxetine (2.70%), nefopam (2.57%), and hydroxyzine (2.17%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study highlighted that anticholinergic and sedative medications to avoid in older people are still frequently prescribed despite the development and regular updating of PIM criteria. Future studies are needed to assess whether this has led to worsened outcomes among older adults who utilized these medications, and new initiatives should be developed to further promote deprescribing by prescribers and pharmacists.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.19324","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T08:08:27Z","timestamp":1735891707000},"page":"1542-1550","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Assessing the prevalence of anticholinergic and sedative medications to avoid in older adults from the French Health Data System"],"prefix":"10.1111","volume":"73","author":[{"given":"Teddy","family":"Novais","sequence":"first","affiliation":[{"name":"Research on Healthcare Performance (RESHAPE) INSERM U1290, University Lyon1  Lyon France"},{"name":"Department of Pharmacy Charpennes Hospital, Hospices Civils de Lyon  Villeurbanne France"},{"name":"University Lyon1  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5611-3608","authenticated-orcid":false,"given":"Antoine","family":"Garnier\u2010Crussard","sequence":"additional","affiliation":[{"name":"University Lyon1  Lyon France"},{"name":"Clinical and Research Memory Centre of Lyon, Charpennes Hospital, Department of Geriatric Medicine Lyon Institute For Aging, Hospices Civils de Lyon  Villeurbanne France"},{"name":"Normandie Univ, UNICAEN, INSERM, U1237, PhIND \u201cPhysiopathology and Imaging of Neurological Disorders,\u201d Neuropresage Team, Cyceron  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9201-2137","authenticated-orcid":false,"given":"Elsa","family":"Reallon","sequence":"additional","affiliation":[{"name":"Research on Healthcare Performance (RESHAPE) INSERM U1290, University Lyon1  Lyon France"},{"name":"Department of Pharmacy Charpennes Hospital, Hospices Civils de Lyon  Villeurbanne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle","family":"Mouchoux","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Charpennes Hospital, Hospices Civils de Lyon  Villeurbanne France"},{"name":"University Lyon1  Lyon France"},{"name":"Eduwell Team Lyon Neuroscience Research Center (CRNL), INSERM U1028, CNRS UMR5292, University Lyon1  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5030-565X","authenticated-orcid":false,"given":"Frederic","family":"Gervais","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Charpennes Hospital, Hospices Civils de Lyon  Villeurbanne France"},{"name":"OMEDIT Auvergne\u2010Rh\u00f4ne\u2010Alpes, Hospices Civils de Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.18773\/austprescr.2022.031"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S66660"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266\u2010015\u20100310\u20109"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228\u2010016\u20102162\u20106"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.18691"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.2165\/11597800\u2010000000000\u201000000"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228\u2010013\u20101499\u20103"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13206"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228\u2010021\u201003145\u20106"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.18372"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s41999\u2010023\u201000777\u2010y"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228\u2010017\u20102257\u20108"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102017\u2010019042"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afad176"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2024.105021"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010147\u20108\u2010200710160\u201000010"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.respe.2017.05.004"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.846"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2007.06.004"},{"key":"e_1_2_12_21_1","unstructured":"WHOCC \u2013 structure and principles. 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