{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:47:13Z","timestamp":1789836433322,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T00:00:00Z","timestamp":1742688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T00:00:00Z","timestamp":1742688000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["345668"],"award-info":[{"award-number":["345668"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We aimed to examine the impact of sedative prescription patterns in hospitalized older adults on post\u2010discharge adverse drug events (ADEs), falls, and sleep.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a secondary analysis of the MedSafer randomized controlled trial (RCT; NCT03272607) which included hospitalized adults\u2009\u2265\u200965\u2009years of age who were taking \u2265\u20095 medications. We identified patients who completed follow\u2010up at 30\u2009days post\u2010discharge and provided patient\u2010reported outcomes for sleep disturbance (PROMIS SD 4a). We grouped patients based on sedative use as follows: nonusers, continued home use (pre\u2010 and post\u2010hospitalization), deprescribed home use, and new use at discharge. Using multivariable logistic regression, we compared the odds of patients having experienced \u2265\u20091 ADE (not necessarily ascribed to sedatives), a fall, or any adverse event within 30\u2009days post\u2010discharge. We also used ordinal logistic regression and a minimal important difference approach to compare the change in sleep disturbance at 30\u2009days post\u2010discharge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The cohort comprised 3630 patients with a median age of 78. A total of 2810 (77.4%) were categorized as nonusers; 475 (13.1%) continued home use; 293 (8.1%) deprescribed home use; and 52 (1.4%) new users at discharge. Compared to the continued home use group, the deprescribed group was substantially less likely to experience an ADE post\u2010discharge (adjusted odds ratio [aOR], 0.39 [95% CI, 0.16\u20130.97]). Correspondingly, new users at discharge had substantially higher odds of falls (aOR, 2.51 [95% CI, 1.13\u20135.61]). Favorable changes in sleep disturbance were more likely among nonusers (aOR, 1.29 [95% CI, 1.05\u20131.58]) and deprescribed users (aOR, 1.11 [95% CI, 0.82\u20131.50]) when compared to continued users.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this cohort, patients who had their sedatives deprescribed were 61% less likely than continued users to have a post\u2010discharge ADE, and new sedative use at discharge was associated with appreciable risk of falls. Hospitalization likely represents a window of opportunity to improve care by promoting sedative deprescription and avoiding new starts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.19437","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T03:16:18Z","timestamp":1742786178000},"page":"1753-1761","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prescribing Patterns and Impact of Sedatives in Hospitalized Older Adults: A Secondary Analysis of the\n                    <scp>MedSafer<\/scp>\n                    Study"],"prefix":"10.1111","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3624-8641","authenticated-orcid":false,"given":"Bennet","family":"Desormeau","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health Sciences McGill University  Montr\u00e9al Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2680-7657","authenticated-orcid":false,"given":"Allen","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Geriatric Medicine University of Ottawa  Ottawa Ontario Canada"},{"name":"The Ottawa Hospital and Ottawa Hospital Research Institute  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Downar","sequence":"additional","affiliation":[{"name":"The Ottawa Hospital and Ottawa Hospital Research Institute  Ottawa Ontario Canada"},{"name":"Division of Palliative Care University of Ottawa  Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter E.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Clinical Pharmacology and Toxicology University of Toronto  Ontario Canada"},{"name":"Division of General Internal Medicine and Geriatrics 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Universit\u00e9 de Montr\u00e9al  Montr\u00e9al Canada"},{"name":"Research Center of Institut Universitaire de g\u00e9riatrie de Montr\u00e9al  Montr\u00e9al Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finlay A.","family":"McAlister","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine University of Alberta  Edmonton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Elsayed","sequence":"additional","affiliation":[{"name":"Clinical Practice Assessment Unit, Department of Medicine McGill University  Montr\u00e9al Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marnie Goodwin","family":"Wilson","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine and Critical Care University of British Columbia  Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo 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