{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:31:23Z","timestamp":1777948283891,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T00:00:00Z","timestamp":1745020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2025,8]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Older adults with multimorbidity have been under\u2010represented in clinical drug trials. We sought to determine willingness to enroll in trials and preferences of older adults for learning about clinical trials, visit frequency, travel, locations, and testing.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Cross\u2010sectional internet and telephone survey of a nationally representative sample of adults \u2265\u200965\u2009years with \u2265\u20093 chronic conditions (\n NORC<\/jats:styled-content>\n University of Chicago Foresight 50+ panel) from March\u2013April 2023 to determine acceptability of aspects of clinical trials.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Surveyed 1318 (1142 Internet, 176 phone), mean age 72.3\u2009\u00b1\u20096.3 (\n SD<\/jats:styled-content>\n ), 52% women; race: 83% White, 10% Black or African American (\n BLAfrAm<\/jats:styled-content>\n ), 5% Hispanic or Latino, 1.1% Asian; 4.4\u2009\u00b1\u20091.9 chronic conditions (of 16 queried), taking 7.5\u2009\u00b1\u20093.3 medications. Almost half would consider trials of medications for memory problems, hypertension, cancer, chronic pain, diabetes, or high cholesterol. Men and\n BLAfrAm<\/jats:styled-content>\n respondents were the most willing to consider hypertension or diabetes trials. Preferences for where to learn about trials were physician offices (87% overall, 85% of\n BLAfrAm<\/jats:styled-content>\n , 94% of Hispanic); 10% of White respondents considered senior centers versus 30% of\n BLAfrAm<\/jats:styled-content>\n and 20% of Hispanics (\n p<\/jats:italic>\n \u2009<\u20090.001). Two\u2010thirds wanted written materials and question and answer sessions (no significant sex or racial differences). Respondents anticipated no difficulty with measuring blood pressure at home, and only respondents >\u200980\u2009years anticipated difficulty wearing activity monitoring devices. All groups preferred monthly or every 3\u20134\u2009month visits for physical exams, blood or urine tests vs. less frequently and were willing to travel half an hour in each direction for visits.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Efforts to increase enrollment of older adults and older adults from previously under\u2010represented racial populations will need increased physician engagement. Pragmatic trials with infrequent participant contact are not likely to increase participation of older adults with multimorbidity.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgs.19470","type":"journal-article","created":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T04:47:11Z","timestamp":1745038031000},"page":"2517-2523","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Preferences Regarding Clinical Drug Trial Elements: A Nationally Representative Survey of Older Adults With Multimorbidity"],"prefix":"10.1111","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5171-7824","authenticated-orcid":false,"given":"Janice B.","family":"Schwartz","sequence":"first","affiliation":[{"name":"University of California San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2770-2147","authenticated-orcid":false,"given":"Ruey\u2010Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"National Chengchi University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3121-9526","authenticated-orcid":false,"given":"John","family":"Boscardin","sequence":"additional","affiliation":[{"name":"University of California San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7426-6387","authenticated-orcid":false,"given":"Derjung M.","family":"Tarn","sequence":"additional","affiliation":[{"name":"University of California Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2020.100670"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2452"},{"key":"e_1_2_10_4_1","unstructured":"National Academies of Sciences Engineering and Medicine \u201cDrug Research and Development for Adults Across the Older Age Span: Proceedings of a Workshop \u201dPaper Presented at: 2021; Washington DC."},{"key":"e_1_2_10_5_1","volume-title":"Inclusion of Older Adults in Clinical Research 2021 Workshop","author":"Research Centers Collaborative Network of the National Institute on Aging","year":"2021"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncimonographs\/lgac023"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.36149"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2020.5084"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15786"},{"key":"e_1_2_10_10_1","volume-title":"Envisioning a Transformed Clinical Trials Enterprise for 2030","author":"National Academies of Sciences E, Medicine","year":"2022"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.18857"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-008-0520-5"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/43.1.62"},{"issue":"9","key":"e_1_2_10_14_1","first-page":"1052","article-title":"Willingness of Minorities to Participate in Biomedical Studies: Confirmatory Findings From a Follow\u2010Up Study Using the Tuskegee Legacy Project Questionnaire","volume":"99","author":"Katz R. V.","year":"2007","journal-title":"Journal of the National Medical Association"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030019"},{"key":"e_1_2_10_16_1","volume-title":"Improving Representation in Clinical Trials and Research: Building Research Equity for Women and Underrepresented Groups","author":"National Academies of Sciences, Engineering, Medicine","year":"2022"},{"key":"e_1_2_10_17_1","unstructured":"Deloitte_Center_for_Health_Solutions \u201cDeloitte 2022 Survey of US Health Care Consumers \u201dBroadening Clinical Trial Participation to Improve Health Equity https:\/\/www2.deloitte.com\/us\/en\/insights\/industry\/health\u2010care\/increasing\u2010diversity\u2010clinical\u2010trials.html2022."},{"key":"e_1_2_10_18_1","unstructured":"Clinical Trials Transformation Initiative \u201cVirtual Public Workshop to Enhance Clinical Study Diversity (FDORA) \u201d2023 https:\/\/ctti\u2010clinicaltrials.org\/virtual\u2010public\u2010workshop\u2010to\u2010enhance\u2010clinical\u2010study\u2010diversity\/."},{"key":"e_1_2_10_19_1","unstructured":"Duke_Margolis_Institute_for_Health_Policy \u201cEnhancing Representative Enrollment Through Point\u2010of\u2010Care Trials \u201d2024 https:\/\/healthpolicy.duke.edu\/sites\/default\/files\/2024\u201006\/Enhancing%20Representative%20Enrollment%20through%20Point\u2010of\u2010Care%20Trials.pdf."},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.35714"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21638"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.16875"},{"key":"e_1_2_10_23_1","unstructured":"S.Espinoza \u201cPreventable Trial: Lessons Learned \u201dPresented at American Geriatric Society 2024 Virtual Annual Meeting 2024."}],"container-title":["Journal of the American Geriatrics Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgs.19470","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T15:54:33Z","timestamp":1762185273000},"score":1,"resource":{"primary":{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/10.1111\/jgs.19470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,19]]},"references-count":22,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1111\/jgs.19470"],"URL":"https:\/\/doi.org\/10.1111\/jgs.19470","archive":["Portico"],"relation":{},"ISSN":["0002-8614","1532-5415"],"issn-type":[{"value":"0002-8614","type":"print"},{"value":"1532-5415","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,19]]},"assertion":[{"value":"2025-01-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}