{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T14:41:12Z","timestamp":1784126472811,"version":"3.55.0"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG065722"],"award-info":[{"award-number":["R01AG065722"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG077620"],"award-info":[{"award-number":["R01AG077620"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG079295"],"award-info":[{"award-number":["R01AG079295"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Antidepressants are prescribed for depression among older adults but might increase the risk of motor vehicle crash (MVC) through adverse effects (AEs) like sedation, dizziness, and blurred vision. Antidepressant subclasses may have different MVC risks since AE risks vary across subclasses. Our objective was to estimate the comparative one\u2010year risks of MVC upon initiating atypical (AA) or tricyclic (TCA) versus selective serotonin reuptake inhibitor (SSRI) antidepressants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We emulated 470 sequential target trials each week from January 6, 2008, through January 1, 2017, using Medicare fee\u2010for\u2010service claims linked to New Jersey police\u2010reported MVCs and driver's licensing data. Our sequential target trial emulation included older adults aged \u2265\u200966\u2009years with a recent diagnosis of depression who initiated AAs, SSRIs, or TCAs. The unit of analysis was the \u201cperson\u2010trial\u201d a unique instance of a person in a sequential trial. Using inverse probability of treatment and censoring weighted Kaplan\u2013Meier estimators to account for potential confounding and selection bias, we estimated the intention\u2010to\u2010treat cumulative incidence and risk ratios (RRs) of MVC over 1\u2009year of follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 13,034 person\u2010trials from 11,604 persons (median [first quartile, third quartile] age: 76.0 [71.0, 82.0] years, 69.8% female, 89.4% non\u2010Hispanic White race). There were 31 (37.6 [95% confidence limits {CLs} 20.3, 59.5] per 1000), 65 (37.6 [95% CLs 25.7, 47.7] per 1000), and 380 (38.0 [95% CLs 24.1, 39.7] per 1000) MVCs among 644 TCA\u2010treated, 2130 AA\u2010treated, and 10,260 SSRI\u2010treated person\u2010trials, respectively. The adjusted RRs were 0.99 (95% CLs 0.72, 1.56) comparing AAs versus SSRIs and 0.99 (95% CLs 0.56, 1.86) comparing TCAs versus SSRIs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We observed no differences in the one\u2010year risk of MVC between antidepressant subclasses. When selecting among antidepressant subclasses to manage depression in older adults, MVC risk should not guide prescribing decisions, and other considerations should take precedence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.19527","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T06:35:54Z","timestamp":1747722954000},"page":"2397-2409","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of Initiating Different Antidepressant Subclasses on Motor Vehicle Crash Risk Among Older Adults With Depression"],"prefix":"10.1111","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0604-5595","authenticated-orcid":false,"given":"Marzan A.","family":"Khan","sequence":"first","affiliation":[{"name":"Department of Epidemiology Brown University School of Public Health  Providence Rhode Island USA"},{"name":"Center for Gerontology and Healthcare Research, Department of Health Services, Policy, and Practice Brown University School of Public Health  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7611-5494","authenticated-orcid":false,"given":"Nina R.","family":"Joyce","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Brown University School of Public Health  Providence Rhode Island USA"},{"name":"Center for Gerontology and Healthcare Research, Department of Health Services, Policy, and Practice Brown University School of Public Health  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa R.","family":"Pfeiffer","sequence":"additional","affiliation":[{"name":"Center for Injury Research and Prevention Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa R.","family":"Riester","sequence":"additional","affiliation":[{"name":"Center for Gerontology and Healthcare Research, Department of Health Services, Policy, and Practice Brown University School of Public Health  Providence Rhode Island USA"},{"name":"Department of Health Services Policy and Practice Brown University School of Public Health  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4899-7116","authenticated-orcid":false,"given":"Brian R.","family":"Ott","sequence":"additional","affiliation":[{"name":"Department of Neurology Brown University  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arman","family":"Oganisian","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Brown University School of Public Health  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison E.","family":"Curry","sequence":"additional","affiliation":[{"name":"Center for Injury Research and Prevention Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"Division of Emergency Medicine Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth A.","family":"Margolis","sequence":"additional","affiliation":[{"name":"Brown University Health  Providence Rhode Island USA"},{"name":"Department of Psychiatry &amp; Human Behavior Brown University  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1673-4570","authenticated-orcid":false,"given":"Andrew R.","family":"Zullo","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Brown University School of Public Health  Providence Rhode Island USA"},{"name":"Center for Gerontology and Healthcare Research, Department of Health Services, Policy, and Practice Brown University School of Public Health  Providence Rhode Island USA"},{"name":"Center of Innovation in Long\u2010Term Services and Supports, Providence Veterans Affairs Medical Center  Providence Rhode Island USA"},{"name":"Department of Pharmacy, Brown University Health Rhode Island Hospital  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,20]]},"reference":[{"key":"e_1_2_14_2_1","unstructured":"Older Drivers \u201cNHTSA \u201daccessed May 9 2024 https:\/\/www.nhtsa.gov\/book\/countermeasures\u2010that\u2010work\/older\u2010drivers."},{"key":"e_1_2_14_3_1","doi-asserted-by":"crossref","unstructured":"A. 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