{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T02:41:13Z","timestamp":1792550473960,"version":"4.5.0"},"reference-count":47,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004426","name":"Atlantic Philanthropies","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004426","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018754","name":"An Roinn Sl\u00e1inte","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018754","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate whether tooth loss is associated with all\u2010cause and cause\u2010specific mortality in older Irish adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 8494 participants from The Irish Longitudinal Study on Ageing (TILDA) were included. Survey data were linked to death registration records, covering individuals who participated in TILDA Wave 1 (2009\/2010) and died by 31st January 2022. Cox proportional hazards regressions and competing risk survival analyses were employed to examine the longitudinal relationship between tooth loss and both all\u2010cause and cause\u2010specific mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean age of participants at baseline was 63.2\u2009years (SD 10.2). Among the cohort, 3951 (46.5%) were categorized as \u201cDentate, no denture,\u201d 3041 (35.8%) as \u201cDentate, with denture(s),\u201d and 1502 (17.7%) as \u201cEdentulous.\u201d Over a median follow\u2010up of 12\u2009years, 1430 (16.8%) participants died. After adjusting for confounders, edentulous participants had a significantly higher hazard ratio (HR) for all\u2010cause mortality compared to dentate participants with no dentures (HR\u2009=\u20091.42, 95% CI 1.23\u20131.65,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). For cause\u2010specific mortality, edentulism had the greatest sub\u2010distribution hazard ratio (SHR) with respiratory mortality (SHR\u2009=\u20091.57, 95% CI 1.03\u20132.41,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04), followed by cancer mortality (SHR\u2009=\u20091.31, 95% CI 1.01\u20131.71,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04). There was a nonsignificant association with cardiovascular mortality (SHR\u2009=\u20091.25, 95% CI 0.96\u20131.63,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.10).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Edentulism was independently associated with all\u2010cause mortality in a cohort of 8494 men and women from Ireland. Edentulism was significantly associated with respiratory and cancer mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.19539","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T09:02:00Z","timestamp":1747645320000},"page":"2431-2440","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Tooth Loss and 12\u2010Year Mortality Risk in 8494 Older Adults From Ireland"],"prefix":"10.1111","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8783-8089","authenticated-orcid":false,"given":"Lewis","family":"Winning","sequence":"first","affiliation":[{"name":"Dublin Dental University Hospital Trinity College Dublin  Dublin Ireland"},{"name":"The Irish Longitudinal Study on Ageing (TILDA) Trinity College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3856-2848","authenticated-orcid":false,"given":"Siobhan","family":"Scarlett","sequence":"additional","affiliation":[{"name":"The Irish Longitudinal Study on Ageing (TILDA) Trinity College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6309-4866","authenticated-orcid":false,"given":"Mark","family":"Ward","sequence":"additional","affiliation":[{"name":"The Irish Longitudinal Study on Ageing (TILDA) Trinity College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4761-5945","authenticated-orcid":false,"given":"Michael","family":"Crowe","sequence":"additional","affiliation":[{"name":"Dublin Dental University Hospital Trinity College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9336-8124","authenticated-orcid":false,"given":"Rose Anne","family":"Kenny","sequence":"additional","affiliation":[{"name":"The Irish Longitudinal Study on Ageing (TILDA) Trinity College Dublin  Dublin Ireland"},{"name":"Mercer's Institute for Successful Ageing St James's Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4529-7664","authenticated-orcid":false,"given":"Brian","family":"O'Connell","sequence":"additional","affiliation":[{"name":"Dublin Dental University Hospital Trinity College Dublin  Dublin Ireland"},{"name":"The Irish Longitudinal Study on Ageing (TILDA) Trinity College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31146-8"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12732"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514537828"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","unstructured":"A.Sheehan C.McGarrigle andB.O'Connell \u201cOral Health and Wellbeing in Older Adults in Ireland \u201d2017 https:\/\/tilda.tcd.ie\/publications\/reports\/OralHealth\/.","DOI":"10.38018\/TildaRe.2017-04"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514546165"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034517693566"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20181773"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2024.06.012"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.837743"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515586352"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13510"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-95865-z"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12808"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13189"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-00488-6"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-2358.1999.00011.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411000110030501"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2012.1397"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515602879"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyy163"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12199"},{"issue":"2","key":"e_1_2_10_23_1","first-page":"169","article-title":"Ransam a Random Sample Design for Ireland","volume":"10","author":"Whelan B. J.","year":"1979","journal-title":"Economic and Social Review"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.12688\/hrbopenres.13083.2"},{"key":"e_1_2_10_25_1","unstructured":"Central Statistics Office \u201cVital Statistics Yearly Summary 2023 \u201daccessed April 23 2025 https:\/\/www.cso.ie\/en\/releasesandpublications\/ep\/p\u2010vsys\/vitalstatisticsyearlysummary2023\/."},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1984.03350140051025"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1999.10474144"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-2097"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034520952401"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030797"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40496-017-0121-7"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514552493"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jopr.12342"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511422909"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jncc.2021.01.002"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-023-02997-x"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyh375"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3402\/jom.v2i0.5195"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910308200209"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm193"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12615"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513505621"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1922\/IDJ_2184Polzer13"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-5712(96)00029-2"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2004.07.011"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1177\/23800844211026608"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2020.103360"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.psych.53.100901.135217"}],"container-title":["Journal of the American Geriatrics Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgs.19539","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T15:55:18Z","timestamp":1762185318000},"score":1,"resource":{"primary":{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/10.1111\/jgs.19539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,19]]},"references-count":47,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1111\/jgs.19539"],"URL":"https:\/\/doi.org\/10.1111\/jgs.19539","archive":["Portico"],"relation":{},"ISSN":["0002-8614","1532-5415"],"issn-type":[{"value":"0002-8614","type":"print"},{"value":"1532-5415","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,19]]},"assertion":[{"value":"2024-11-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}