{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T13:49:22Z","timestamp":1793627362796,"version":"4.5.1"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23AG055666"],"award-info":[{"award-number":["K23AG055666"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U24 AG082930"],"award-info":[{"award-number":["U24 AG082930"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The prevalence of both chronic kidney disease (CKD) and Alzheimer's disease (AD) increases with age. With the rise in average life expectancy, clinicians will be more likely to encounter patients with both CKD and cognitive concerns, including some with AD neuropathology. The prevalence of AD neuropathology and the nature of the interaction between AD neuropathology and vascular brain alterations in individuals with CKD are unclear.<\/jats:p>\n                  <jats:p>AD blood\u2010based biomarkers (BBM) are promising tools for detecting AD neuropathology and are being reviewed by the FDA for clinical use. However, AD BBMs do not perform reliably in CKD and can be elevated even in the absence of AD neuropathology (false positive). AD cerebrospinal fluid (CSF) biomarkers are also altered in CKD, further complicating the detection of AD neuropathology in this population.<\/jats:p>\n                  <jats:p>It is important for clinicians to understand the limitations of AD BBMs and perhaps CSF biomarkers in the real world, where there is a higher prevalence of CKD and other comorbidities compared to the population samples in which they have been studied. Even if the prevalence of AD neuropathology in CKD is not higher than that in the general population, it is important to accurately detect AD neuropathology among individuals with CKD, so that the new anti\u2010amyloid monoclonal antibodies can be used appropriately. This special article addresses the concerns with the use of AD BBM in the detection of AD neuropathology and the caution needed while using AD BBMs in clinical care.<\/jats:p>","DOI":"10.1111\/jgs.19554","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T10:00:23Z","timestamp":1750154423000},"page":"2995-3001","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Detection of Alzheimer's Disease Neuropathology in Chronic Kidney Disease: Current State and Future Directions"],"prefix":"10.1111","volume":"73","author":[{"given":"Aditi","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle M.","family":"Mielke","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Prevention Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre N.","family":"Tariot","sequence":"additional","affiliation":[{"name":"Banner Alzheimer's Institute  Phoenix Arizona USA"},{"name":"University of Arizona College of Medicine  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2016.10.014"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000012113"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.16954"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.0629"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.5216"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.120.050686"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.3090"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000480"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14184"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12787"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010022\u201001822\u20102"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/0886022x.2011.560402"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000207419"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12614"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13859"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010024\u201000989\u20101"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.7326\/m14\u20100743"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12581"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1681\/asn.0000000000000167"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102022\u2010330540"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e318142774e"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2015.11.008"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.13855"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010024\u201001513\u20109"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43856\u2010023\u201000333\u20106"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14150"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft509"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.322"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2875"}],"container-title":["Journal 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