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We aimed to determine if muscle area and density at the L1 and L3 vertebra and right and left proximal thigh were similarly related to functional outcomes and 10\u2010year mortality risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Men from the Osteoporotic Fractures in Men (MrOS) study who had CT images, measures of grip strength, 6\u2009m walking speed, and leg power (Nottingham Power Rig) at the baseline visit were included in the analyses (<jats:italic>n<\/jats:italic>\u2009=\u20093290, 73.7\u2009\u00b1\u20095.8\u2009years). CT images were automatically segmented to derive muscle area and muscle density. Deaths were centrally adjudicated over a 10\u2010year follow\u2010up. Linear regression and proportional hazards were used to model relationships of CT muscle metrics with functional outcomes and mortality, respectively, while adjusting for covariates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Muscle area and density were positively related to functional outcomes regardless of anatomical region, with the most variance explained in leg power (adjusted <jats:italic>R<\/jats:italic>\n<jats:sup>2<\/jats:sup>\u2009=\u20090.40\u20130.46), followed by grip strength (adjusted <jats:italic>R<\/jats:italic>\n<jats:sup>2<\/jats:sup>\u2009=\u20090.25\u20130.29) and walking speed (adjusted <jats:italic>R<\/jats:italic>\n<jats:sup>2<\/jats:sup>\u2009=\u20090.18\u20130.20). A one\u2010unit SD increase in muscle area and density was associated with a 5%\u201313% and 8%\u201321% decrease in the risk of all\u2010cause mortality, respectively, with the strongest associations observed at the right and left thigh.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Automated measures of CT muscle area and density are related to functional outcomes and risk of mortality in older men, regardless of CT anatomical region.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgs.19583","type":"journal-article","created":{"date-parts":[[2025,7,13]],"date-time":"2025-07-13T11:40:24Z","timestamp":1752406824000},"page":"2717-2726","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Associations of <scp>CT<\/scp> Muscle Area and Density With Functional Outcomes and Mortality Across Anatomical Regions in Older Men"],"prefix":"10.1111","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1825-8010","authenticated-orcid":false,"given":"Megan","family":"Hetherington\u2010Rauth","sequence":"first","affiliation":[{"name":"California Pacific Medical Center Research Institute  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler A.","family":"Mansfield","sequence":"additional","affiliation":[{"name":"California Pacific Medical Center Research Institute  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Lenchik","sequence":"additional","affiliation":[{"name":"Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley A.","family":"Weaver","sequence":"additional","affiliation":[{"name":"Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy M.","family":"Cawthon","sequence":"additional","affiliation":[{"name":"California Pacific Medical Center Research Institute  San Francisco California USA"},{"name":"University of California Department of Epidemiology and Biostatistics  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.15.14635"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.17.18214"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1259350"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.14283\/jfa.2020.16"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glab266"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0000000000000059"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.90.6.2157"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/61.10.1059"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0193241"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/60.7.882"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2002.50217.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glx262"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glv016"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2009.02366.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-021-00812-9"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/60.3.324"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.222937"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glaa141"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2020.154321"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gln031"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glv027"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/61.1.72"},{"issue":"4","key":"e_1_2_9_24_1","first-page":"513","article-title":"Body Composition Remodeling and Mortality: The Health Aging and Body Composition Study","volume":"72","author":"Santanasto A. 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