{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:50:56Z","timestamp":1791618656834,"version":"4.3.4"},"reference-count":45,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011251","name":"Northern Ontario Academic Medicine Association","doi-asserted-by":"publisher","award":["A\u201019\u201010"],"award-info":[{"award-number":["A\u201019\u201010"]}],"id":[{"id":"10.13039\/100011251","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recent studies suggest that respiratory syncytial virus (RSV) can cause severe illness in terms of in\u2010hospital outcomes and mortality. The degree to which RSV hospitalization is associated with cardiovascular outcomes, particularly those known to occur following acute respiratory infections, is poorly described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective cohort study of adults aged \u2265\u200965\u2009years hospitalized with a diagnosis of RSV, influenza, urinary tract infection (UTI), or fracture between 2011 and 2020 in Ontario, Canada. Outcomes included subsequent heart failure, myocardial infarction, stroke, or atrial fibrillation events up to 1\u2010year post\u2010discharge, as well as in\u2010hospital and acute outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cardiovascular events were subsequently identified in 18.5% (<jats:italic>n<\/jats:italic>\u2009=\u2009474\/2558) of patients who had an RSV\u2010related hospitalization, compared to 17.7% (2961\/16,688), 12.1% (8908\/73,587), and 8.4% (941\/11,262) of patients initially hospitalized with influenza, UTI, or fracture, respectively. In matched analyses, RSV hospitalization was associated with a greater rate of subsequent heart failure events relative to all other patient groups (HR range, 1.48\u20133.74), both in patients with or without pre\u2010existing cardiovascular conditions. The rate of atrial fibrillation events was also higher in RSV patients, although this was dependent on pre\u2010existing cardiovascular conditions and the comparator group considered. RSV patients were also more likely to be transferred to intensive care (OR range, 1.48\u20133.55) and had a higher rate of mortality (HR range, 1.49\u20133.98).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest that RSV is an important determinant of serious post\u2010discharge cardiovascular outcomes in older adults. Further, they underline the importance of vaccination in this population, regardless of pre\u2010existing risk factors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgs.19591","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T07:01:07Z","timestamp":1753254067000},"page":"2685-2694","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Respiratory Syncytial Virus (<scp>RSV<\/scp>)\u2010Related Hospitalization and Increased Rate of Cardiovascular Events in Older Adults"],"prefix":"10.1111","volume":"73","author":[{"given":"Chris P.","family":"Verschoor","sequence":"first","affiliation":[{"name":"Health Sciences North Research Institute  Sudbury Ontario Canada"},{"name":"Northern Ontario School of Medicine University  Sudbury Ontario Canada"},{"name":"Department of Medicine McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua O.","family":"Cerasuolo","sequence":"additional","affiliation":[{"name":"ICES North  Sudbury Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph M.","family":"Caswell","sequence":"additional","affiliation":[{"name":"Health Sciences North Research Institute  Sudbury Ontario Canada"},{"name":"ICES North  Sudbury Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Tatangelo","sequence":"additional","affiliation":[{"name":"Health Sciences North Research Institute  Sudbury Ontario Canada"},{"name":"ICES North  Sudbury Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atilio","family":"Costa\u2010Vitali","sequence":"additional","affiliation":[{"name":"Health Sciences North Research Institute  Sudbury Ontario Canada"},{"name":"Northern Ontario School of Medicine University  Sudbury Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Savage","sequence":"additional","affiliation":[{"name":"Health Sciences North Research Institute  Sudbury Ontario Canada"},{"name":"Northern Ontario School of Medicine University  Sudbury Ontario Canada"},{"name":"ICES North  Sudbury Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey C.","family":"Kwong","sequence":"additional","affiliation":[{"name":"ICES  Toronto Ontario Canada"},{"name":"Public Health Ontario  Toronto Ontario Canada"},{"name":"Department of Family and Community Medicine and Dalla Lana School of Public Health University of Toronto  Toronto Ontario Canada"},{"name":"University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2024.2383504"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2027906"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7321a3"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","unstructured":"P. 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