{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:48:16Z","timestamp":1787165296619,"version":"build-2736575974"},"reference-count":56,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004375","name":"Tel Aviv University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004375","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Potentially inappropriate prescribing (PIP), encompassing potentially inappropriate medications (PIMs) and prescribing omissions (PPOs), is prevalent among older adults and consistently associated with adverse health outcomes. However, evidence on its impact on mortality remains limited. We examined the associations of PIMs and PPOs with long\u2010term mortality in a cohort of community\u2010dwelling older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>One thousand two hundred and ten participants from the third follow\u2010up (1999\u20132007) of a longitudinal prospective cohort study were followed for mortality until 03\/2022. PIMs and PPOs were identified using the 2023 Beers and the Screening Tool of Older Persons' Potentially Inappropriate Prescriptions\/Screening Tool to Alert doctors to Right Treatment (STOPP\/START) v3 criteria. Cox proportional hazards and Fine\u2013Gray subdistribution hazard models assessed associations between PIP and all\u2010cause and non\u2010cancer mortality, respectively, adjusting for sociodemographic, lifestyle, and health\u2010related factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 81.2% of participants were exposed to &gt;\u20091 problem: 52.6% and 45.0% to PIMs based on Beers and STOPP criteria, respectively, and 59.3% to PPOs. In multivariable analysis, exposure to \u2265\u20092 PIMs was associated with increased all\u2010cause mortality for Beers (HR\u2009=\u20091.31, 95% CI: 1.04\u20131.69) and STOPP (HR\u2009=\u20091.25, 95% CI: 1.00\u20131.55) criteria. An interaction between PIMs (Beers criteria) and self\u2010rated health (SRH) indicated stronger associations for those with \u201cexcellent\/good\u201d baseline SRH, compared to those with \u201cpoor\/very poor\u201d SRH (\n                      <jats:italic>p<\/jats:italic>\n                      \u2010for\u2010interaction\u2009=\u20090.030). Use of \u2265\u20092 PIMs was also associated with a 1.4\u2010fold increased non\u2010cancer mortality risk for both tools. Exposure to \u2265\u20092 PPOs was associated with a 1.8\u2010fold increase in all\u2010cause mortality risk (HR\u2009=\u20091.84, 95% CI: 1.24\u20132.72), while associations were stronger in men (\n                      <jats:italic>p<\/jats:italic>\n                      \u2010for\u2010interaction\u2009=\u20090.012). Exposure to 1 or \u2265\u20092 PPOs was also associated with 1.3 and 2.0\u2010fold increased non\u2010cancer mortality risk, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PIP is prevalent and is associated with increased long\u2010term mortality among community\u2010dwelling older adults. Addressing PIMs in healthier older individuals and reducing PPOs in clinical practice is critical. Sex\u2010specific pharmaceutical guidelines are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.70002","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T07:29:53Z","timestamp":1754897393000},"page":"2828-2838","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A Prospective Study on Potentially Inappropriate Drug Use and All\u2010Cause Mortality in Community\u2010Dwelling Older Adults"],"prefix":"10.1111","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9464-9123","authenticated-orcid":false,"given":"Liat","family":"Orenstein","sequence":"first","affiliation":[{"name":"Public Health Research Center Gertner Institute for Epidemiology and Health Policy Research, Sheba Medical Center  Ramat\u2010Gan Israel"},{"name":"Department of Epidemiology and Preventive Medicine, School of Public Health, Gray Faculty of Medical and Health Sciences Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7129-5497","authenticated-orcid":false,"given":"Angela","family":"Chetrit","sequence":"additional","affiliation":[{"name":"Public Health Research Center Gertner Institute for Epidemiology and Health Policy Research, Sheba Medical Center  Ramat\u2010Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keren","family":"Laufer","sequence":"additional","affiliation":[{"name":"Pharmaceutics Registration Department, Teva Israel Ltd.  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