{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:27:12Z","timestamp":1791581232217,"version":"4.3.4"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,7,27]],"date-time":"2025-07-27T00:00:00Z","timestamp":1753574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K24AG073527"],"award-info":[{"award-number":["K24AG073527"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG075335"],"award-info":[{"award-number":["R01AG075335"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG081412"],"award-info":[{"award-number":["R01AG081412"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Prolonged benzodiazepine (BZD) use following hospital discharge may heighten the risk of BZD dependence and serious adverse drug events in older adults. However, there is limited understanding of BZD discontinuation pattern and associated factors in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study was conducted using Optum CDM from January 2004 to February 2025. We included patients aged \u2265\u200965\u2009years who newly initiated a BZD prescription within 30\u2009days of hospitalization. We excluded patients with anxiety, mental illnesses, alcohol abuse, seizure disorder, and those receiving hospice care. BZD discontinuation was defined as a gap exceeding 15\u2009days following the end of a BZD prescription. Discontinuation rates were estimated by the Kaplan\u2013Meier method, and the association between patient characteristics and BZD discontinuation was analyzed using Cox proportional hazards models in the primary analysis. Inverse probability of censoring weight was applied to adjust for the competing risk of death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 33,449 patients were included (mean age [SD]: 73.1 [5.8]\u2009years; 51.7% men). The IPW\u2010weighted BZD discontinuation rate by 30, 60, and 90\u2009days was 53.3% (95% CI: 52.7%\u201353.8%), 86.7% (86.3%\u201387.1%), and 92.6% (92.3%\u201393.0%), respectively. The 30\u2010day discontinuation rate increased from 31.7% (29.5%\u201333.9%) in 2004 to 71.1% (68.7%\u201373.5%) in 2024. During the study period, an annual 4% increase in the discontinuation rate was observed. Risk factors associated with lower BZD discontinuation were insomnia (hazard ratio [HR]: 0.66 [0.63\u20130.69]), moderate\u2010to\u2010severe frailty (HR: 0.82 [0.75\u20130.90]), and new uses of antidepressants (HR: 0.80 [0.76\u20130.85]) and atypical antipsychotics (HR: 0.90 [0.82\u20130.99]) following hospitalization and before the first BZD prescription.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Discontinuation rates of BZDs following hospitalization in older adults without a psychiatry history have increased over time. However, challenges remain in discontinuing BZDs, particularly among individuals with insomnia and moderate\u2010to\u2010severe frailty, which may be target populations for developing effective deprescribing strategies in the future.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.70018","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T03:33:28Z","timestamp":1753673608000},"page":"3074-3084","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pattern and Associated Factors of Benzodiazepine Discontinuation Among Older Adults Following Hospitalization"],"prefix":"10.1111","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5747-6806","authenticated-orcid":false,"given":"Chun\u2010Ting","family":"Yang","sequence":"first","affiliation":[{"name":"Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Wilkins","sequence":"additional","affiliation":[{"name":"Division of Geriatric Psychiatry, McLean Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3836-2440","authenticated-orcid":false,"given":"Kevin T.","family":"Pritchard","sequence":"additional","affiliation":[{"name":"Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoxi","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7290-6838","authenticated-orcid":false,"given":"Dae Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife Harvard Medical School  Boston Massachusetts USA"},{"name":"Division of Gerontology, Department of Medicine Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kueiyu Joshua","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Medicine, Massachusetts General Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.18372"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-018-0544-4"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.17947"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.12788\/jhm.2739"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40360-017-0183-0"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2019.05.004"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-007-0194-4"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-015-3501-5"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39276.489780.DB"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ps.202100617"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-019-05098-0"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-020-00799-2"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.16751"},{"key":"e_1_2_10_15_1","unstructured":"Centers for Medicare & Medicaid Services \u201cMedicare Skilled Nursing Facility (SNF) Transparency Data (CY2013) \u201d Accessed May 6 2025 https:\/\/www.cms.gov\/newsroom\/fact\u2010sheets\/medicare\u2010skilled\u2010nursing\u2010facility\u2010snf\u2010transparency\u2010data\u2010cy2013."},{"key":"e_1_2_10_16_1","volume-title":"Amid the COVID\u201019 Pandemic, Medicare Spending on Skilled Nursing Facilities Increased More Than 4% Despite an Overall Decline in Utilization","author":"Biniek J. 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