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However, most studies define PN by loss of protective sensation alone, a late form of PN. We aimed to quantify the prevalence and risk factors of PN in very old community\u2010dwelling adults regardless of diabetes using the Michigan Neuropathy Screening Instrument (MNSI), a validated screening tool.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a cross\u2010sectional analysis of participants aged 78\u2013100\u2009years old in the Atherosclerosis Risk in Communities Study (2022\u20132023). PN was defined by a score &gt;\u20092 on the MNSI physical examination or \u2265\u20097 on the MNSI questionnaire. We report the prevalence rates and age\u2010, sex\u2010, race\u2010center\u2010adjusted odds ratios (aOR) of PN\u2010associated covariates using logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 1068 participants (median age 84.1\u2009years, SD 3.9; 40.0% male; 17.6% Black; 26.8% with diabetes), 62.4% had PN. MNSI\u2010detected PN was present in 67.5% of participants with diabetes, 61.7% with prediabetes, and 60.2% without diabetes (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.14). Covariates associated with PN included advanced age (\u2265\u200990\u2009years vs. 75\u201380\u2009year: aOR 2.92), male sex vs. female sex: (aOR 2.38), taller height (height quartile 4 vs1: aOR 2.32), low short physical performance battery scores (vs. highest scores: aOR 2.35), hypertension (aOR 1.56), and lumbosacral stenosis (aOR 1.76). In a sensitivity analysis, PN prevalence was lower when using the monofilament test (38.9%) compared to the MNSI (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Diabetes was significantly associated with PN when assessed using monofilament testing for loss of protective sensation (aOR: 1.85; 95% CI: 1.31\u20132.61) compared to the MNSI (aOR: 1.42; 95% CI: 1.00\u20132.03).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PN detected by the MNSI is highly prevalent among very old adults, regardless of diabetes status. The MNSI detected a higher prevalence of PN in older adults compared to the monofilament test. Routine screening of high\u2010risk adults using the MNSI may be warranted to facilitate early detection and management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.70041","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T12:08:44Z","timestamp":1756728524000},"page":"3530-3538","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Prevalence of Peripheral Neuropathy Among Very Old Adults: Evidence From the Michigan Neuropathy Screening Instrument"],"prefix":"10.1111","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4253-6615","authenticated-orcid":false,"given":"Y. H. 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