{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:04:02Z","timestamp":1791299042716,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000933","name":"Hearst Foundations","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000933","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UM1TR004409"],"award-info":[{"award-number":["UM1TR004409"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UM1TR004528"],"award-info":[{"award-number":["UM1TR004528"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG066546"],"award-info":[{"award-number":["P30AG066546"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG072980"],"award-info":[{"award-number":["P30AG072980"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R56AG074467"],"award-info":[{"award-number":["R56AG074467"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["OT2HL161841"],"award-info":[{"award-number":["OT2HL161841"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["OT2HL161847"],"award-info":[{"award-number":["OT2HL161847"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2025,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n This study evaluated the impact of aging on the frequency and prevalent symptoms of Long COVID, also termed post\u2010acute sequelae of SARS\u2010CoV\u20102, using a previously developed Long COVID research index (LCRI) of 41 self\u2010reported symptoms in which those with 12 or more points were classified as likely to have Long COVID.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We analyzed community\u2010dwelling participants \u2265\u200960\u2009years old (2662 with prior infection, 461 controls) compared to participants 18\u201359\u2009years (7549 infected, 728 controls) in the Researching COVID to Enhance Recovery adult (RECOVER\u2010Adult) cohort \u2265\u2009135\u2009days post\u2010onset.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Compared to the Age 18\u201339 group, the adjusted odds of LCRI \u2265\u200912 were higher for the Age 40\u201349 group (odds ratio [OR]\u2009=\u20091.40, 95% confidence intervals [CI]\u2009=\u20091.21\u20131.61,\n p<\/jats:italic>\n \u2009<\u20090.001) and 50\u201359 group (OR\u2009=\u20091.31, CI\u2009=\u20091.14\u20131.51,\n p<\/jats:italic>\n \u2009<\u20090.001), similar for the Age 60\u201369 group (OR\u2009=\u20091.09, CI\u2009=\u20090.93\u20131.27,\n p<\/jats:italic>\n \u2009=\u20090.299), and lower for the \u2265\u200970 group (OR\u2009=\u20090.68, CI\u2009=\u20090.54\u20130.85,\n p<\/jats:italic>\n \u2009<\u20090.001). Participants \u2265\u200970\u2009years had smaller adjusted differences between infected and uninfected symptom prevalence rates than those aged 18\u201339 for the following symptoms: hearing loss, fatigue, pain (including joint, back, chest pain and headache), post\u2010exertional malaise, sleep disturbance, hair loss, palpitations, and sexual desire\/capacity, making these symptoms less discriminating for Long COVID in older adults than in younger. Symptom clustering, as described in Thaweethai et\u00a0al. (JAMA 2023) also exhibited age\u2010related shifts: clusters 1 (anosmia and ageusia) and 2 (gastrointestinal, chronic cough and palpitations, without anosmia, ageusia or brain fog) were more likely, and clusters 3 (brain fog, but no loss of smell or taste) and 4 (a mix of symptoms) less likely to be found in older adults (relative risk ratios for clusters 3\u20134 ranging from 0.10\u20130.34,\n p<\/jats:italic>\n \u2009<\u20090.001 vs. 18\u201339\u2009year\u2010olds).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Within the limits of this observational study, we conclude that in community\u2010dwelling older adults, aging alters the prevalence and pattern of reported Long COVID.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgs.70043","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T11:59:15Z","timestamp":1756727955000},"page":"3123-3137","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Age\u2010Related Changes in the Clinical Picture of Long\n COVID<\/scp>"],"prefix":"10.1111","volume":"73","author":[{"given":"Mindy J.","family":"Fain","sequence":"first","affiliation":[{"name":"Arizona Center on Aging University of Arizona College of Medicine\u2010Tucson Tucson Arizona USA"},{"name":"Division of General Internal Medicine, Geriatrics and Palliative Medicine, Department of Medicine University of Arizona College of Medicine\u2010Tucson Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin D.","family":"Horne","sequence":"additional","affiliation":[{"name":"Intermountain Heart Institute Intermountain Health Salt Lake City Utah USA"},{"name":"Division of Cardiovascular Medicine, Department of Medicine Stanford University School of Medicine Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leora I.","family":"Horwitz","sequence":"additional","affiliation":[{"name":"Center for Healthcare Innovation and Delivery Science NYU Langone Health New York New York USA"},{"name":"Departments of Medicine and of Population Health NYU Grossman School of Medicine New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanayott","family":"Thaweethai","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Biostatistics Harvard University Boston Massachusetts USA"},{"name":"Department of Medicine Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith","family":"Greene","sequence":"additional","affiliation":[{"name":"Indiana University Center for Aging Research at the Regenstrief Institute Indianapolis Indiana USA"},{"name":"Department of Medicine Indiana University School of Medicine Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7572-3092","authenticated-orcid":false,"given":"Mady","family":"Hornig","sequence":"additional","affiliation":[{"name":"The Feinstein Institutes for Medical Research, Northwell Health Manhasset New York USA"},{"name":"RECOVER Patient Representative New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariela R.","family":"Orkaby","sequence":"additional","affiliation":[{"name":"New England Geriatric Research, Education and Clinical Center (GRECC), VA Boston Healthcare System; 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