{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:50:57Z","timestamp":1792083057785,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The long\u2010term prognosis of patients with heart failure (HF) remains poor. Most patients with HF are older, and multiple factors involved in geriatric syndromes are associated with worse long\u2010term prognosis. Sarcopenia is a major component of geriatric syndrome. Early diagnosis and therapeutic intervention for sarcopenia are clinically important in patients with HF; however, the prevalence and long\u2010term prognostic impact of sarcopenia in patients with stage B HF remain unclear. This study aimed to determine the prevalence of sarcopenia in older patients with stage B HF and its impact on the long\u2010term prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The PAPRIKA\u2010HF study was a multicenter, prospective study that enrolled outpatients \u2265\u200965\u2009years who were diagnosed with stage B HF. Sarcopenia was assessed based on the Asian Working Group for Sarcopenia 2019 diagnostic criteria. The primary endpoint was a composite endpoint (all\u2010cause mortality, incident myocardial infarction, or hospitalization for heart failure) of &gt;\u20092\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 312 patients (mean age: 78.2\u2009\u00b1\u20096.5\u2009years, 45% female), 17.7% (56 of 312 patients) had sarcopenia. The rate of the composite endpoint over 2\u2009years was significantly higher in patients with sarcopenia than in those without (25.0% vs. 2.7%, log\u2010rank test,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Multivariate analysis using the Cox proportional hazards model showed that sarcopenia was an independent predictor of long\u2010term prognosis (hazard ratio: 5.78, 95% confidence interval: 2.16\u201315.43,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Sarcopenia was associated with a worse long\u2010term prognosis in older patients with stage B HF, highlighting the importance of early diagnosis of sarcopenia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.70046","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T12:06:39Z","timestamp":1756469199000},"page":"3105-3112","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Prevalence and Prognostic Implication of Sarcopenia Among Patients With Stage B Heart Failure: The\n                    <scp>PAPRIKA<\/scp>\n                    \u2010\n                    <scp>HF<\/scp>\n                    Cohort Study"],"prefix":"10.1111","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9089-3505","authenticated-orcid":false,"given":"Koichiro","family":"Matsumura","sequence":"first","affiliation":[{"name":"Department of Cardiology Kindai University Faculty of Medicine  Osakasayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Morishita","sequence":"additional","affiliation":[{"name":"Morishita Heart Clinic  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Morimoto","sequence":"additional","affiliation":[{"name":"Department of Cardiology Arida Municipal Hospital  Arida Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Kurose","sequence":"additional","affiliation":[{"name":"Health Science Center Kansai Medical University Hospital  Hirakata Japan"},{"name":"Faculty of Sport and Health Sciences Osaka Sangyo University  Daito Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohei","family":"Hakozaki","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kindai University Faculty of Medicine  Osakasayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eijiro","family":"Yagi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kindai University Faculty of Medicine  Osakasayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Ueno","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kindai University Faculty of Medicine  Osakasayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Kimura","sequence":"additional","affiliation":[{"name":"Health Science Center Kansai Medical University Hospital  Hirakata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaku","family":"Nakazawa","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kindai University Faculty of Medicine  Osakasayama 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