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However, little is known about the negative outcomes associated with multiple central nervous system (CNS)\u2010active medications that are commonly prescribed to these patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the association between the number of CNS\u2010active medications at discharge and the risk of 1\u2010year all\u2010cause hospital readmission, drug\u2010related hospital readmission (DRA), death, quality of life (QoL) and functional status in older multimorbid adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Among 2008 older multimorbid inpatients with polypharmacy, we assessed the association between the number of CNS\u2010active medications and 1\u2010year all\u2010cause hospital readmission, DRA, and death by Cox proportional hazard models. We further assessed the association of the number of CNS\u2010active medications with QoL (measured with EQ\u20105D\u2010VAS) and functional status (measured with Barthel Index) using binary and quantile regression models. Analyses were adjusted for age, sex, discharge location, Charlson Comorbidity Index, depression\/anxiety, and randomization arm. Additional sensitivity analyses were adjusted for the number of non\u2010CNS active medications, neurological and psychiatric comorbidities, alcohol or tobacco use, education level, and living arrangements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The risk of all\u2010cause hospital readmission and DRA increased by 7% with each additional CNS\u2010active medication (multivariable\u2010adjusted hazard ratio (HR) 1.07 (95% confidence interval 1.03 to 1.12) for all\u2010cause hospital readmission and 1.07 (1.01 to 1.14) for DRA). HR for death was 1.14 (1.07 to 1.23) for each additional CNS\u2010active medication. The mean differences in EQ\u20105D\u2010VAS and Barthel Index after 1\u2009year were \u22122.13 (\u22122.82 to \u22121.44) and \u22121.6 (\u22122.16 to \u22121.04) respectively, per additional CNS\u2010active medication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The presence of CNS\u2010active medications at discharge is associated with a higher risk for 1\u2010year all\u2010cause hospital readmission and DRA in older multimorbid adults with polypharmacy. Additionally, CNS\u2010active medications were associated with lower QoL and functional status.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trail Registration:<\/jats:bold>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      NCT02986425\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.70049","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T12:05:10Z","timestamp":1756469110000},"page":"3113-3122","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Central Nervous System\u2010Active Medications and Risk of Hospital Readmission in Older Multimorbid Adults"],"prefix":"10.1111","volume":"73","author":[{"given":"Mirah J.","family":"Stuber","sequence":"first","affiliation":[{"name":"Department of General Internal Medicine Inselspital, Bern University Hospital, University of Bern  Bern Switzerland"},{"name":"Institute of Primary Health Care (BIHAM), University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara A.","family":"Brockhus","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine Inselspital, Bern University Hospital, University of Bern  Bern Switzerland"},{"name":"Institute of Primary Health Care (BIHAM), University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Spinewine","sequence":"additional","affiliation":[{"name":"Clinical Pharmacy and Pharmacoepidemiology Research Group, Louvain Drug Research Institute Universit\u00e9 Catholique de Louvain  Belgium"},{"name":"Department of Pharmacy CHU UCL Namur  Yvoir 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