{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:15:13Z","timestamp":1787238913174,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sodium\u2010glucose cotransporter\u20102 (SGLT2) inhibitors, developed for type 2 diabetes mellitus (T2DM), have demonstrated cardiorenal benefits in conditions including cardiovascular (CV) disease. However, few meta\u2010analyses have synthesized outcomes in older adults with CV disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review and meta\u2010analysis of randomized controlled trials published from January 2015 to January 2025 was conducted using MEDLINE (PubMed), Embase (Ovid), and CENTRAL. We included studies that reported the risk of CV outcomes for subgroups of older adults (\u2265\u200965\u2009years) with CV disease. The primary outcome was a composite of hospitalization for heart failure (HHF), urgent heart failure (HF) visits, and cardiovascular death (CVD). Secondary outcomes included all\u2010cause mortality, CVD, and HHF individually. Subgroup analyses were conducted in patients with HF, T2DM, age strata (65\u201374 vs. \u2265\u200975), SGLT2 inhibitor agent, and adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Analyzing nine studies, SGLT2 inhibitors were associated with reducing the risk of composite outcome (HR: 0.75, 95% CI: 0.67\u20130.83,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200951%), all\u2010cause mortality (HR: 0.80, 95% CI: 0.66\u20130.97,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200968%), CVD (HR: 0.78, 95% CI: 0.65\u20130.94,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200961%), and HHF (HR: 0.73, 95% CI: 0.65\u20130.83,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090%). Benefits were consistent in subgroups of HF only, T2DM only, and those aged \u2265\u200975\u2009years. No significant differences were observed by SGLT2 inhibitor type (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.090). SGLT2 inhibitors increased the risk of genital infections (RR: 3.18, 95% CI: 2.35\u20134.30,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090%) but decreased that of other serious adverse events (RR: 0.92, 95% CI: 0.86\u20130.97,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200964%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In adults aged \u2265\u200965\u2009years with CV disease, SGLT2 inhibitors significantly reduce the composite risk of HHF, urgent HF visits, and CVD and secondary outcomes of all\u2010cause mortality, CVD, and HHF, supporting their use in this population with careful monitoring of age\u2010related risks.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.70143","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T07:02:19Z","timestamp":1759820539000},"page":"3708-3718","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["<scp>SGLT2<\/scp>\n                    Inhibitors in Older Adults With Cardiovascular Disease: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6903-7723","authenticated-orcid":false,"given":"Kota","family":"Minami","sequence":"first","affiliation":[{"name":"Medical Training Center Saga University Hospital  Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rika","family":"Terashima","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health Stanford University School of Medicine  Stanford California USA"},{"name":"Department of Medicine Jacobi Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Freeman","sequence":"additional","affiliation":[{"name":"Department of Medicine Ashikaga Red Cross Hospital  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Yamada","sequence":"additional","affiliation":[{"name":"Brookdale Department of Geriatrics and Palliative Medicine Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda R.","family":"Vest","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Heart, Vascular, and Thoracic Institute Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Yano","sequence":"additional","affiliation":[{"name":"Department of General Medicine Juntendo University Faculty of Medicine  Tokyo Japan"},{"name":"Center for Medical Innovation Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Naito","sequence":"additional","affiliation":[{"name":"Department of General Medicine Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Miyashita","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Heart, Vascular, and Thoracic Institute Cleveland Clinic  Cleveland Ohio USA"},{"name":"Department of General Medicine Juntendo University Faculty of Medicine  Tokyo Japan"},{"name":"Pulmonary and Critical Care Medicine Division Cleveland Clinic Foundation  Cleveland Ohio 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