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The trial will enroll participants meeting the following inclusion criteria: (1) \u2265\u200970\u2009years of age, (2) with low to moderate physical function, defined as self\u2010reported difficulty walking 1\/4 mile or climbing a flight of stairs, but able to walk 400\u2009m at baseline exam, (3) usual walking speed between \u2265\u20090.44 and &lt;\u20091.0\u2009m\/s on a 4\u2010m walk or a body mass index of \u2265\u200928\u2009kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    , (4) average IL\u20106 level between 2.0 and 30\u2009pg\/mL on two tests, and (5) no active infection, cancer, or other serious health conditions. Clazakizumab, a monoclonal antibody targeting IL\u20106, 5\u2009mg via subcutaneous injection every 4\u2009weeks for 24\u2009weeks compared to a placebo. The primary outcome will be walking speed over 400\u2009m. Secondary outcomes include other measures of physical function (short physical performance battery, oxygen consumption with walking on a treadmill, fatigability), cognitive function, vascular stiffness and endothelial function, IL\u20106 and C\u2010reactive protein levels, other markers of inflammation, safety, and tolerability. Findings will evaluate acceptability, safety and 6\u2010months change in mobility and other outcomes. The study was approved by the IRB and is registered with\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                    (NCT05727384). The RIGHT study will inform the geroscience hypothesis that modifying aging itself will lead to improvement in multiple aspects of health.\n                  <\/jats:p>","DOI":"10.1111\/jgs.70272","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T17:14:14Z","timestamp":1768065254000},"page":"636-647","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The \u201cReducing Inflammation for Greater Health Trial (\n                    <scp>RIGHT<\/scp>\n                    )\u201d Study\u2014Concept, Rationale, and Design"],"prefix":"10.1111","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3945-6828","authenticated-orcid":false,"given":"Sebastian E.","family":"Sattui","sequence":"first","affiliation":[{"name":"Department of Medicine, School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania 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