{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:27:13Z","timestamp":1791826033036,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004037","name":"Juho Vainion S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004037","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007753","name":"It\u00e4-Suomen Yliopisto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007753","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010116","name":"Medicinska Underst\u00f6dsf\u00f6reningen Liv och H\u00e4lsa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010116","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004212","name":"P\u00e4ivikki ja Sakari Sohlbergin S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004212","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["137826"],"award-info":[{"award-number":["137826"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013500","name":"Diabetestutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013500","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005633","name":"Syd\u00e4ntutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003125","name":"Suomen Kulttuurirahasto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003125","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2026,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n The impact of vitamin D on fall incidence remains controversial. We studied the effect of 5\u2009years of vitamin D\n 3<\/jats:sub>\n supplementation on the risk of falls in a double\u2010blind, placebo\u2010controlled randomized trial with generally healthy, community\u2010dwelling men and women in Finland.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The study included 2495 participants, men aged \u2265\u200960 and women aged \u2265\u200965, who were randomized into three arms: 1600\u2009IU\/day or 3200\u2009IU\/day of vitamin D\n 3<\/jats:sub>\n or placebo. A random subgroup of 551 participants underwent more detailed examinations. Falls and fall\u2010related injuries were collected with questionnaires at months 0, 12, 24, 36, and 60. General linear mixed models and generalized linear models were used for analyses.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Over the 5\u2010year follow\u2010up, a similar fall risk of 55% and fall\u2010injury risk of 11% were observed in the placebo, 1600\u2009IU\/day, and 3200\u2009IU\/day arms, with the mean number of falls and fall\u2010injuries per person\u2010year of 1.26 (95% CI 1.14\u20131.38) and 0.07 (95% CI 0.06\u20130.08), respectively. Age, sex, or BMI did not modify the results. In the random subgroup, the mean baseline serum 25(OH)D concentration was 75\u2009nmol\/L (SD 18). After 12\u2009months, the concentrations were 73, 100, and 120\u2009nmol\/L in the placebo, 1600\u2009IU\/day, and 3200\u2009IU\/day arms, respectively.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Five\u2010year vitamin D\n 3<\/jats:sub>\n supplementation of 1600\u2009IU\/day or 3200\u2009IU\/day did not affect the overall risk of falls or fall injuries among generally healthy, largely vitamin D sufficient men and women. The findings do not support the use of high vitamin D doses for fall prevention in such populations.\n <\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n \n ClinicalTrials.gov<\/jats:ext-link>\n : NCT01463813,\n https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01463813<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgs.70295","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T07:51:21Z","timestamp":1768377081000},"page":"1548-1557","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Effect of Vitamin\n \n D\n 3<\/sub>\n <\/scp>\n Supplementation on the Risk of Falls in a General Population\u2014The Finnish Vitamin D Trial"],"prefix":"10.1111","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5948-1222","authenticated-orcid":false,"given":"Toni","family":"Rikkonen","sequence":"first","affiliation":[{"name":"Institute of Clinical Medicine University of Eastern Finland Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5330-3847","authenticated-orcid":false,"given":"Sari","family":"Hantunen","sequence":"additional","affiliation":[{"name":"Institute of Public Health and Clinical Nutrition University of Eastern Finland Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heikki","family":"Kr\u00f6ger","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Traumatology and Hand Surgery Kuopio University Hospital Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7326-1904","authenticated-orcid":false,"given":"Christel","family":"Lamberg\u2010Allardt","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9426-7595","authenticated-orcid":false,"given":"JoAnn E.","family":"Manson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Brigham and Women's Hospital Harvard Medical School and the Department of Epidemiology Harvard T.H. Chan School of Public Health Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarja","family":"Nurmi","sequence":"additional","affiliation":[{"name":"Institute of Public Health and Clinical Nutrition University of Eastern Finland Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6391-3071","authenticated-orcid":false,"given":"Marjo","family":"Tuppurainen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine University of Eastern Finland Kuopio Finland"},{"name":"Department of Obstetrics and Gynecology Kuopio University Hospital Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0664-2675","authenticated-orcid":false,"given":"Ari","family":"Voutilainen","sequence":"additional","affiliation":[{"name":"Institute of Public Health and Clinical Nutrition University of Eastern Finland Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomi\u2010Pekka","family":"Tuomainen","sequence":"additional","affiliation":[{"name":"Institute of Public Health and Clinical Nutrition University of Eastern Finland Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0648-999X","authenticated-orcid":false,"given":"Jyrki K.","family":"Virtanen","sequence":"additional","affiliation":[{"name":"Institute of Public Health and Clinical Nutrition University of Eastern Finland Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7235a1"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/injuryprev\u20102019\u2010043286"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afl084"},{"key":"e_1_2_10_5_1","unstructured":"World Health Organization \u201cWHO Global Report on Falls Prevention in Older Age. 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