{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:11:16Z","timestamp":1791886276610,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG065249"],"award-info":[{"award-number":["R01AG065249"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017016","name":"Geriatric Research Education and Clinical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR000445"],"award-info":[{"award-number":["UL1 TR000445"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Delirium afflicts 17% of older emergency department (ED) patients and 25% of older hospitalized patients. This form of acute brain failure is associated with accelerated cognitive decline. We conducted a randomized controlled trial to determine whether early cognitive intervention improved 4\u2010month global cognition in older ED patients hospitalized with delirium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A two\u2010site randomized controlled trial was conducted with English\u2010speaking patients aged 65\u2009years or older who were delirious at enrollment. Patients were excluded if they had end\u2010stage dementia, resided in a nursing home, or were in hospice. Patients were randomized to receive a cognitive intervention within 24\u2009h of ED presentation or usual care in a 1:2 ratio. Patients randomized to cognitive intervention received twice\u2010daily cognitive training sessions during hospitalization and weekly cognitive rehabilitation for up to 12\u2009weeks after hospital discharge. The primary outcome was global cognition at 4\u2009months using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), with higher scores indicating better cognition. To determine the effect of the cognitive intervention on 4\u2010month global cognition, proportional odds logistic regression was performed, adjusted for pre\u2010illness dementia and function, and other confounders. Adjusted odds ratios (aORs) and their 95% confidence intervals (95% CIs) are reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 283 patients were randomized; 97 were randomized into the cognitive intervention arm, and 186 were randomized into the usual care arm. A total of 152 patients had 4\u2010month RBANS data. The median interquartile range (IQR) RBANS score at 4 months was 67 (49, 80) and 67 (52, 83) in the intervention and usual care groups, respectively. In the adjusted analysis, the cognitive intervention was not significantly associated with 4\u2010month RBANS (aOR\u2009=\u20090.86; 95% CI: 0.45, 1.65).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Early cognitive intervention was not associated with improved 4\u2010month global cognition in older ED patients hospitalized with delirium.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.70372","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T07:19:02Z","timestamp":1776410342000},"page":"1274-1284","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Effect of an Early Cognitive Intervention on Global Cognition in Older Hospitalized Adults With Delirium"],"prefix":"10.1111","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0384-210X","authenticated-orcid":false,"given":"Jin H.","family":"Han","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Critical Illness, Brain Dysfunction, and Survivorship (CIBS) Center, Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Geriatric Research, Education, and Clinical Center (GRECC), Veterans Affairs Tennessee Valley Healthcare System  Nashville Tennessee USA"},{"name":"Veterans' Wellbeing Through Innovation, Systems Science and Experience in Learning Health Systems (VETWISE\u2010LHS), Tennessee Valley Veterans Affairs Healthcare System  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Critical Illness, Brain Dysfunction, and Survivorship (CIBS) Center, Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Geriatric Research, Education, and Clinical Center (GRECC), Veterans Affairs Tennessee Valley Healthcare System  Nashville Tennessee USA"},{"name":"Division of Allergy, Pulmonary, and Critical Care Medicine Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard E.","family":"Vasilevskis","sequence":"additional","affiliation":[{"name":"Division of Hospital Medicine University of Wisconsin  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanchao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy A.","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariu C.","family":"Duggan","sequence":"additional","affiliation":[{"name":"Geriatric Research, Education, and Clinical Center (GRECC), Veterans Affairs Tennessee Valley Healthcare System  Nashville Tennessee USA"},{"name":"Division of Geriatrics Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. Zeynep","family":"Kubilay","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine and Public Health Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Thompson","sequence":"additional","affiliation":[{"name":"Critical Illness, Brain Dysfunction, and Survivorship (CIBS) Center, Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly M.","family":"Moser","sequence":"additional","affiliation":[{"name":"Vanderbilt Institute for Clinical and Translational Research (VICTR), Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patsy T.","family":"Bryant","sequence":"additional","affiliation":[{"name":"Critical Illness, Brain Dysfunction, and Survivorship (CIBS) Center, Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen F.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Vanderbilt Institute for Clinical and Translational Research (VICTR), Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse O.","family":"Wrenn","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Schnelle","sequence":"additional","affiliation":[{"name":"Division of Geriatrics Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"Dittus","sequence":"additional","affiliation":[{"name":"Geriatric Research, Education, and Clinical Center (GRECC), Veterans Affairs Tennessee Valley Healthcare System  Nashville Tennessee USA"},{"name":"Veterans' Wellbeing Through Innovation, Systems Science and Experience in Learning Health Systems (VETWISE\u2010LHS), Tennessee Valley Veterans Affairs Healthcare System  Nashville Tennessee USA"},{"name":"Division of General Internal Medicine and Public Health Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3957-2172","authenticated-orcid":false,"given":"E. 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