{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T01:58:22Z","timestamp":1785463102428,"version":"3.56.0"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG073586"],"award-info":[{"award-number":["AG073586"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS041588"],"award-info":[{"award-number":["NS041588"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U01DK106858"],"award-info":[{"award-number":["U01DK106858"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To understand cross\u2010sectional associations between lower urinary tract symptoms (LUTS) and specific cognitive domains, we examined cognitive performance in older adults with and without LUTS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study comprised a subset of Black and White participants, aged 45 and older, enrolled in the REasons for Geographic and Racial Differences in Stroke (REGARDS) national, longitudinal cohort study 2003\u20132007. Computer\u2010assisted telephone interviews were conducted for follow\u2010up every 6\u2009months including an established cognitive battery: Six\u2010Item Screener (SIS) for cognitive impairment, animal naming, letter F naming, word list learning, and delayed recall for verbal fluency\/executive function and verbal memory. Validated LUTS questionnaires were administered beginning in 2020 at 6\u2010month intervals. Separate linear and logistic regression models for men and women estimated associations between LUTS and cognitive battery scores, adjusting for covariates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From the 10,464 participants (6026 women, 4438 men), 70% of women reported LUTS (mean age 69\u2009\u00b1\u20098\u2009years) versus 62% of men (mean age 63\u2009\u00b1\u20097\u2009years). More Black men reported LUTS compared to White men, 69% versus 59% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), respectively, without differences among Black and White women. Men and women with LUTS had decreased odds of being cognitively intact based on the SIS, OR 0.65, 95% CI 0.50, 0.85 and OR 0.64, 95% CI 0.46, 0.78, respectively. Men with LUTS had lower scores for Animal Naming (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u22120.42, 95% CI \u22120.75, \u22120.08) and Delayed Recall (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u22120.18, 95% CI \u22120.30, \u22120.05). Women with LUTS had lower test scores for Letter F Naming (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u22120.29, 95% CI \u22120.55, \u22120.04), Word List Learning (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u22120.40, 95% CI \u22120.68, \u22120.11) and Delayed Recall (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u22120.13, 95% CI \u22120.25, \u22120.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Older adults with LUTS have subtle differences in cognitive function, especially in new learning, verbal memory, and verbal fluency\/executive function that should be considered in treatment decisions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.70382","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T04:17:31Z","timestamp":1775708251000},"page":"2041-2049","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lower Urinary Tract Symptoms and Cognitive Impairment Among Participants in the\n                    <scp>REGARDS<\/scp>\n                    Cohort Study"],"prefix":"10.1111","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6567-6744","authenticated-orcid":false,"given":"Alayne D.","family":"Markland","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Geriatrics, Eccles School of Medicine University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gerontology, Geriatrics, and Palliative Care, Heersink School of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Crowe","sequence":"additional","affiliation":[{"name":"Department of Psychology, College of Art and Science University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9443-101X","authenticated-orcid":false,"given":"Belinda","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gerontology, Geriatrics, and Palliative Care, Heersink School of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cami","family":"Munoz","sequence":"additional","affiliation":[{"name":"Department of Urology Duke University Health System  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Elgayar","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gerontology, Geriatrics, and Palliative Care, Heersink School of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn L.","family":"Burgio","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gerontology, Geriatrics, and Palliative Care, Heersink School of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia J.","family":"Howard","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464\u2010410X.2009.08427.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41391\u2010022\u201000610\u2010w"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.21.2381"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.09.019"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2006.09.045"},{"key":"e_1_2_11_7_1","unstructured":"\u201cNeurocognitive Disorders. 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