{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T21:00:15Z","timestamp":1790456415217,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG074044"],"award-info":[{"award-number":["R01 AG074044"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK128837"],"award-info":[{"award-number":["R01 DK128837"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K24 HL152440"],"award-info":[{"award-number":["K24 HL152440"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL158022"],"award-info":[{"award-number":["R01 HL158022"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Comprehensive data on the burden of biochemical hypoglycemia in older adults with type 2 diabetes are lacking. We seek to characterize the burden and risk factors for hypoglycemia detected by continuous glucose monitoring (CGM) in older adults with type 2 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional analysis of 315 older adults with type 2 diabetes who attended visit 9 of the Atherosclerosis Risk in Communities Study (2021\u20132022). We examined rates of Level 1\u2009hypoglycemia (&lt;\u200970\u2009mg\/dL) and percentage meeting recommended targets for hypoglycemia (&lt;\u20091% of time). We identified risk factors for CGM\u2010detected hypoglycemia by comparing the median time spent in hypoglycemia across subgroups. All analyses were stratified by high\u2010risk medication use (insulin\/sulfonylureas vs. not).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 315 participants with type 2 diabetes (mean age 83\u2009years, 55% women, 41% Black adults), 32.4% were using insulin or sulfonylureas. Among individuals using these high\u2010risk medications, the median time spent in hypoglycemia was 3.4%, and ~66% of participants spent more than 1% of the time with CGM glucose &lt;\u200970\u2009mg\/dL. Hypoglycemic episodes typically occurred overnight and lasted a median of ~1.5\u2009h among individuals using insulin or sulfonylureas. CGM\u2010detected hypoglycemia was low in participants not using high\u2010risk medications (median time spent in hypoglycemia: 0.7%). In unadjusted analyses, cardiovascular disease, cognitive impairment, poor physical functioning, and chronic kidney disease were associated with increased time spent in hypoglycemia, regardless of high\u2010risk medication use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>There may be a substantial burden of unrecognized CGM\u2010detected hypoglycemia in very old adults with type 2 diabetes using high\u2010risk medications in the general population. Hypoglycemia may also be present among persons not on high\u2010risk medication, but the burden is much lower. Further research is needed to clarify the clinical significance of these hypoglycemic episodes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.70412","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T06:52:01Z","timestamp":1775026321000},"page":"2530-2537","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Burden and Risk Factors of\n                    <scp>CGM<\/scp>\n                    \u2010Detected Hypoglycemia in Older Adults With Type 2 Diabetes"],"prefix":"10.1111","volume":"74","author":[{"given":"Michael","family":"Fang","sequence":"first","affiliation":[{"name":"Department of Epidemiology and the Welch Center for Prevention, Epidemiology and Clinical Research Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2257-0480","authenticated-orcid":false,"given":"Natalie Rula","family":"Daya","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and the Welch Center for Prevention, Epidemiology and Clinical Research Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yein","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Health Informatics University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin B.","family":"Echouffo\u2010Tcheugui","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and the Welch Center for Prevention, Epidemiology and Clinical Research Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"},{"name":"Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. Gwen","family":"Windham","sequence":"additional","affiliation":[{"name":"Department of Medicine, MIND Center University of Mississippi Medical Center  Jackson Mississippi USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Zeger","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Selvin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and the Welch Center for Prevention, Epidemiology and Clinical Research Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland 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