{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T01:58:18Z","timestamp":1785463098883,"version":"3.56.0"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100005977","name":"Kaiser Permanente","doi-asserted-by":"publisher","award":["KP\u2010RRC\u201020240504"],"award-info":[{"award-number":["KP\u2010RRC\u201020240504"]}],"id":[{"id":"10.13039\/100005977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Short\u2010acting sulfonylureas are preferred over long\u2010acting sulfonylureas due to reduced risk of hypoglycemia in older adults. Whether older patients can be transitioned from long\u2010acting to short\u2010acting sulfonylureas with equivalent glycemic control while experiencing fewer emergency department (ED) visits or hospitalizations due to hypoglycemia is unknown. We investigated whether the conversion of long\u2010acting glimepiride to short\u2010acting glipizide led to equivalent glycemic control and whether it was associated with reduced ED or hospital utilization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective\u2010cohort study of 625 Kaiser Permanente Southern California members between ages 64 and 110\u2009years old dispensed glimepiride between 03\/15\/2023 and 03\/14\/2024. The conversion to glipizide occurred at the dispensing pharmacy after the index date in March 2024. The co\u2010primary outcomes were to determine whether glycemic control could be maintained with the conversion of one sulfonylurea to another based on a follow\u2010up HgbA1c at 6 to 12\u2010weeks post\u2010conversion while reducing ED utilization or hospitalization for patients within 2 and 4\u2010months of the index date.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 625 patients eligible for the intervention, 472 converted to glipizide and 153 remained on glimepiride. Results 6 to 12\u2010weeks post\u2010index date showed no difference in HgbA1c between those who remained on glimepiride (mean\u2009=\u20097.8; SD\u2009=\u20091.3) and those who converted (mean\u2009=\u20097.8; SD\u2009=\u20091.1). For risk of ED or hospitalization from hypoglycemia, no significant difference was found within 2\u2009months (OR: 0.68, 95% CI: 0.34, 1.36) after adjusting for age and comorbidities. Those who converted to glipizide had lower risk of ED or hospitalization within 4\u2010months (OR: 0.49, 95% CI: 0.29, 0.85) than patients remaining on glimepiride.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients 64\u2009years and older converted from long\u2010acting to short\u2010acting sulfonylureas had no change in glycemic control, and lower rates of ED or hospital utilization at 4\u2010months were observed. This paper reaffirms the Beers Criteria statement that shorter\u2010acting sulfonylureas are preferred over longer\u2010acting sulfonylureas.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.70494","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T13:46:08Z","timestamp":1778161568000},"page":"1971-1978","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Glycemic Control and Utilization Risk With the Conversion of Glimepiride to Glipizide in Adults 64\u2009Years and Older at an Integrated Health Care System"],"prefix":"10.1111","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6049-4052","authenticated-orcid":false,"given":"Eric A.","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Southern California Permanente Medical Group  West Los Angeles California USA"},{"name":"Department of Clinical Science Kaiser Permanente Bernard J. Tyson School of Medicine  Pasadena California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane C.","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Research &amp; Evaluation Kaiser Permanente Southern California  Pasadena California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Kanter","sequence":"additional","affiliation":[{"name":"Department of Clinical Science Kaiser Permanente Bernard J. Tyson School of Medicine  Pasadena California USA"},{"name":"Department of Research &amp; Evaluation Kaiser Permanente Southern California  Pasadena California USA"},{"name":"Department of Health Systems Science Kaiser Permanente Bernard J. Tyson School of Medicine  Pasadena California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy I.","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Southern California Permanente Medical Group  West Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Southern California Permanente Medical Group  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill S.","family":"Silverman","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Southern California Permanente Medical Group  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica A.","family":"Yoshinaga","sequence":"additional","affiliation":[{"name":"Department of Drug Use Management Kaiser Permanente Southern California  Downey California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gene","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Drug Use Management Kaiser Permanente Southern California  Downey California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marit F.","family":"Asrat","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Southern California Permanente Medical Group  West Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel Y.","family":"Kohanim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Southern California Permanente Medical Group  West Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin I.","family":"Broder","sequence":"additional","affiliation":[{"name":"Department of Health Systems Science Kaiser Permanente Bernard J. 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