{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:45:02Z","timestamp":1792687502416,"version":"4.5.0"},"reference-count":56,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009104","name":"Department of Health Research, India","doi-asserted-by":"publisher","award":["R.11014\/06\/2023\u2010GIA\/HR"],"award-info":[{"award-number":["R.11014\/06\/2023\u2010GIA\/HR"]}],"id":[{"id":"10.13039\/501100009104","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To evaluate the efficacy of adjunct probiotic supplementation (\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Lactobacillus helveticus<\/jats:italic>\n                      <\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Bifidobacterium longum<\/jats:italic>\n                      <\/jats:styled-content>\n                      ) alongside standard care compared to placebo in older adults with moderate unipolar depression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A randomized, double\u2010blind, placebo\u2010controlled pilot trial was conducted at two tertiary centers. Fifty\u2010eight participants (\u2265\u200960\u2009years) with moderate depression were randomized 1:1 to receive daily probiotics or a placebo for 12\u2009weeks, alongside standard antidepressant care. They were followed up for another 12\u2009weeks. The primary outcome was depression response (\u2265\u200950% Montgomery\u2010\u00c5sberg Depression Rating Scale [MADRS] score reduction). Secondary outcomes included anxiety (General Anxiety Disorder 7\u2010Item [GAD\u20107]), cognition, quality of life (WHOQOL\u2010BREF), serum brain\u2010derived neurotropic factor (BDNF), and gut microbiota profile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mixed\u2010effects models showed significant improvement over time in depressive symptoms (MADRS:\n                      <jats:italic>F<\/jats:italic>\n                      \u2009=\u200932.0,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and anxiety (GAD\u20107:\n                      <jats:italic>F<\/jats:italic>\n                      \u2009=\u200913.1,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Overall scores were lower in the probiotic group compared with the placebo group for both MADRS (\n                      <jats:italic>F<\/jats:italic>\n                      \u2009=\u200912.7,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) and GAD\u20107 (\n                      <jats:italic>F<\/jats:italic>\n                      \u2009=\u200910.7,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), although group \u00d7 time interactions were not significant. Quality\u2010of\u2010life domains improved markedly (all\n                      <jats:italic>F<\/jats:italic>\n                      \u2009&gt;\u2009100,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) without additional benefit from probiotics. Escitalopram\u2010equivalent antidepressant dose and benzodiazepine use influenced selected outcomes. The probiotic group also had a significantly higher serum BDNF level and increased fecal abundance of supplemented strains vs. the placebo group. The attrition rate was &gt;\u200950% over 24\u2009weeks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this pilot PRODG trial, adjunct probiotics produced modest overall advantages for depressive and anxiety symptoms compared with placebo but did not enhance quality\u2010of\u2010life beyond usual improvement \u2212\u00a0both groups improved substantially, and trajectories over 24\u2009weeks were largely parallel across follow\u2010up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.70530","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T07:01:21Z","timestamp":1781679681000},"page":"2021-2031","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of Adjunct\n                    <scp>PRObiotics<\/scp>\n                    as Compared to the Standard Care in Moderate Unipolar Depression Among Geriatric Patients: A Randomized Double\u2010Blind Placebo\u2010Controlled Pilot Multi\u2010Center Trial (\n                    <scp>PRODG<\/scp>\n                    )"],"prefix":"10.1111","volume":"74","author":[{"given":"Preeti","family":"Sinha","sequence":"first","affiliation":[{"name":"Department of Psychiatry National Institute of Mental Health and Neurosciences  Bengaluru India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasun","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preethy","family":"Kathiresan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karishma 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