{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T22:04:28Z","timestamp":1789855468217,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Restrictive transfusion (Hb\u2009&lt;\u20097\u2009g\/dL) is recommended for most perioperative patients, but the optimal threshold for those with cardiovascular disease or Hb 7\u201310\u2009g\/dL remains uncertain. The Perioperative Transfusion Trigger Score (POTTS), which integrates adrenaline requirement, FiO\n                      <jats:sub>2<\/jats:sub>\n                      , temperature, and angina history, may standardize decisions and safely reduce transfusions in older non\u2010cardiac surgery patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This multicenter RCT in two Chinese hospitals randomized patients\u2009\u2265\u200960\u2009years undergoing non\u2010cardiac surgery 1:1 to POTTS or control. POTTS\u2009=\u20096 plus points for adrenaline, FiO\n                      <jats:sub>2<\/jats:sub>\n                      (to maintain SpO\n                      <jats:sub>2<\/jats:sub>\n                      \u2009\u2265\u200995%), core temperature, and angina; transfusion when Hb\u2009&lt;\u2009POTTS. Control followed 2012 AABB guideline (Hb\u2009&lt;\u20097 always transfuse; &gt;\u200910 not; 7\u201310 physician discretion). Primary outcome: proportion receiving allogeneic RBC transfusion during perioperative period (ITT population).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      253 patients (mean age 72.3\u2009years; 67.6% women) were randomized (May 2023\u2010Sept 2025). Baseline Hb similar (median 9.60 vs. 9.50\u2009g\/dL). In ITT, transfusion required in 24.00% (30\/125) of POTTS vs. 35.94% (46\/128) of control (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.038). Transfusion volume did not differ significantly (median 2.50 vs. 3.00\u2009units,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.520). Overall complication rates: 12.80% vs. 8.59% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.279); one death in control group (0.85%). No significant differences in specific complications.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients \u2265\u200960\u2009years undergoing non\u2010cardiac surgery, POTTS\u2010guided transfusion significantly reduced the proportion of patients transfused without increasing complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      This study was registered at\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.chictr.org.cn\">http:\/\/www.chictr.org.cn<\/jats:ext-link>\n                      (#ChiCTR2300071739)\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.70575","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T22:18:09Z","timestamp":1782857889000},"page":"2564-2572","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Perioperative Transfusion Trigger Score Versus Restrictive Transfusion in Older Non\u2010Cardiac Surgery Patients: A Multicenter Randomized Controlled Trial"],"prefix":"10.1111","volume":"74","author":[{"given":"Shucong","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology The Third Affiliated Hospital of Guangxi Medical University  Nanning Guangxi China"},{"name":"Department of Anesthesiology The Second Naning People's Hospital  Nanning Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The Third Affiliated Hospital of 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