{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T14:32:12Z","timestamp":1793457132047,"version":"4.5.0"},"reference-count":49,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UM1TR005296"],"award-info":[{"award-number":["UM1TR005296"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000133","name":"Agency for Healthcare Research and Quality","doi-asserted-by":"publisher","award":["R18HS029122"],"award-info":[{"award-number":["R18HS029122"]}],"id":[{"id":"10.13039\/100000133","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K23HL153582"],"award-info":[{"award-number":["K23HL153582"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Older adults with cognitive disorders, including dementia and mild cognitive impairment, are particularly vulnerable to adverse effects from centrally acting medications. Cognitive potentially inappropriate medications (CogPIMs), including anticholinergics, antipsychotics, benzodiazepines (BZDs), and non\u2010benzodiazepine hypnotics (Z\u2010drugs), may worsen well\u2010being and increase healthcare utilization in this population. This study evaluates CogPIMs exposure and its association with health\u2010related quality of life (HRQoL) and healthcare utilization among community\u2010dwelling older adults with cognitive disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a cross\u2010sectional analysis of 2011\u20132022 Medical Expenditure Panel Survey (MEPS) data from adults aged \u2265\u200965 with cognitive disorders. CogPIMs exposure was defined as \u2265\u20091 prescription of anticholinergics, antipsychotics, BZDs, or Z\u2010drugs. Outcomes included (1) annual prevalence of CogPIMs exposure, (2) healthcare utilization, and (3) HRQoL measured by SF\u201012 physical and mental component scores. Inverse probability of treatment weighting was used to adjust for confounding. Temporal trends were assessed using Joinpoint regression. Survey\u2010weighted logistic and negative binomial regression models estimated adjusted associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 2796 older adults with cognitive disorders were identified in MEPS from 2011 to 2022, representing a weighted analytic sample of 29.7 million individuals. Overall CogPIM exposure declined from 39.3% in 2011 to 29.3% in 2022 (Annual Percentage Change: \u22121.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). CogPIM exposure was not associated with poor physical HRQoL but was associated with higher odds of poor mental HRQoL (adjusted Odds Ratio: 1.72 [1.31\u20132.25],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). CogPIM exposure was also associated with higher rates of emergency department visits (adjusted incidence rate ratios (aIRR)\u2009=\u20091.41 [1.24\u20131.60],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) and hospitalizations (aIRR\u2009=\u20091.38 [1.19\u20131.59],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), but not outpatient visits (aIRR\u2009=\u20091.27 [0.75\u20131.54],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.31).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among community\u2010dwelling older adults with cognitive disorders, CogPIM exposure remains common and is associated with poorer mental HRQoL and increased acute care utilization. Future longitudinal and interventional studies are needed to determine whether modifying exposure to CogPIM can improve well\u2010being and reduce potentially preventable acute care utilization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.70607","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T09:03:17Z","timestamp":1785834197000},"page":"2888-2897","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cognitive Potentially Inappropriate Medications, Quality of Life, and Healthcare Use in Older Adults With Cognitive Disorders"],"prefix":"10.1111","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7422-9544","authenticated-orcid":false,"given":"Haowen","family":"Hsu","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice School of Pharmacy and Pharmaceutical Sciences, University at Buffalo  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3509-9779","authenticated-orcid":false,"given":"Collin M.","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice School of Pharmacy and Pharmaceutical Sciences, University at Buffalo  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Feuerstein","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice School of Pharmacy and Pharmaceutical Sciences, University at Buffalo  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G.","family":"Wahler","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice School of Pharmacy and Pharmaceutical Sciences, University at Buffalo  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjit","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Jacobs School of Medicine and Biomedical Sciences, University at Buffalo  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9240-7067","authenticated-orcid":false,"given":"David M.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice School of Pharmacy and Pharmaceutical Sciences, University at Buffalo  Buffalo New York 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