{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T14:32:14Z","timestamp":1793457134247,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD096221"],"award-info":[{"award-number":["R01HD096221"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG065722"],"award-info":[{"award-number":["R01AG065722"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG065722\u2010S1"],"award-info":[{"award-number":["R01AG065722\u2010S1"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG079295"],"award-info":[{"award-number":["R01AG079295"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>People with Alzheimer's disease and related dementias (ADRD) are at increased risk of motor vehicle crash (MVC) due to cognitive decline, which often begins years before diagnosis. MVC could serve as an indicator of ADRD\u2010related cognitive impairment and facilitate earlier diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a matched cohort study of Medicare beneficiaries in New Jersey aged \u2265\u200969\u2009years with incident ADRD diagnoses from 2010 to 2017 compared to individuals without ADRD and with four other medical conditions: acute myocardial infarction (AMI), asthma, chronic obstructive pulmonary disease (COPD), and diabetes. Comparison groups were sampled with replacement and matched on sex, age, and calendar quarter of diagnosis or claim (for the non\u2010ADRD group). Crash prevalence at 6\u2009months and 1, 2, and 3\u2009years before diagnosis was compared using chi\u2010square tests, and the monthly prevalence was plotted to examine longitudinal trends in crashes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 43,115 eligible individuals with incident ADRD diagnosis from 2010 to 2017. MVC crash prevalence was higher in the ADRD group than in non\u2010ADRD and negative control groups at all measured pre\u2010diagnosis time points: 6\u2009months (2.99% vs. 2.31%\u20132.53%), 1\u2009year (5.26% vs. 4.18%\u20134.65%), 2\u2009years (9.52% vs. 7.88%\u20138.67%), and 3\u2009years (13.64% vs. 11.29%\u201312.37%). The ADRD group was more likely to have multiple crashes in the pre\u2010diagnosis period, but multiple events were rare overall (&lt;\u20093%). Differences were statistically significant but represented small changes in prevalence. Crash prevalence did not reveal a clear signal of cognitive decline in the years leading up to the index diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Older adults with ADRD had slightly higher prevalence of MVC in the 3\u2009years before diagnosis than matched comparison groups, but absolute differences were small and recurrent crashes were rare. MVC alone is too rare to serve as a signal of incipient ADRD, highlighting the need for more sensitive measures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.70630","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T15:30:52Z","timestamp":1786030252000},"page":"2947-2955","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Motor Vehicle Crash as an Early Signal of Alzheimer's Disease and Related Dementias"],"prefix":"10.1111","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7611-5494","authenticated-orcid":false,"given":"Nina R.","family":"Joyce","sequence":"first","affiliation":[{"name":"Department of Epidemiology Brown University School of Public Health  Providence Rhode Island USA"},{"name":"Center for Gerontology and Health Care Research Brown University School of Public Health  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Balog","sequence":"additional","affiliation":[{"name":"Center for Gerontology and Health Care Research Brown University School of Public Health  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Gaither","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Brown University School of Public Health  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa R.","family":"Pfeiffer","sequence":"additional","affiliation":[{"name":"Center for Injury Research and Prevention Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Bhondoekhan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Brown University School of Public Health  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4899-7116","authenticated-orcid":false,"given":"Brian R.","family":"Ott","sequence":"additional","affiliation":[{"name":"Department of Neurology Warren Alpert Medical School of Brown University  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth A.","family":"Margolis","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Rhode Island Hospital and Warren Alpert Medical School of Brown University  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison E.","family":"Curry","sequence":"additional","affiliation":[{"name":"Center for Injury Research and Prevention Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"Department of General Pediatrics University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1673-4570","authenticated-orcid":false,"given":"Andrew R.","family":"Zullo","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Brown University School of Public Health  Providence Rhode Island USA"},{"name":"Center for Gerontology and Health Care Research Brown University School of Public Health  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2003.51481.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.12.2448"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000294469.27156.30"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.13806"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.5014\/ajot.2017.027581"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h3029"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00066-1"},{"issue":"5","key":"e_1_2_9_9_1","first-page":"S281","article-title":"Early Diagnosis of Alzheimer's Disease: Clinical and Economic Benefits","volume":"51","author":"Leifer B. 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