{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:03:15Z","timestamp":1790874195571,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Transcatheter aortic valve replacement (TAVR) is the standard treatment for older adults with symptomatic severe aortic stenosis. While cardiovascular predictors of long\u2010term mortality after TAVR are well established, the impact of geriatric factors beyond short\u2010term outcomes remains poorly defined. The main objective was to evaluate the association between geriatric factors and five\u2010year all\u2010cause mortality in patients aged 75\u2009years and older undergoing TAVR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study is a single\u2010center retrospective analysis of prospectively collected data at Nantes University Hospital, France. All consecutive patients aged \u2265\u200975\u2009years who underwent\n                      <jats:styled-content style=\"fixed-case\">TAVR<\/jats:styled-content>\n                      between January 2012 and December 2018 and received a standardized pre\u2010procedural geriatric assessment were included. Geriatric assessment included nutritional status, physical performance, functional status, cognition, comorbidities, and frailty assessed using the Rockwood Clinical Frailty Scale (\n                      <jats:styled-content style=\"fixed-case\">CFS<\/jats:styled-content>\n                      ). Multivariate cox regression was used to identify factors independently associated with mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 976 patients included, median age was 84\u2009years and 48% were men. Five\u2010year mortality was 46%. In multivariate analysis, frailty assessed by the\n                      <jats:styled-content style=\"fixed-case\">CFS<\/jats:styled-content>\n                      was independently but modestly associated with five\u2010year mortality (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      1.12; 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      1.01\u20131.26). No other geriatric variables were independently associated with five\u2010year mortality. Five\u2010year mortality increased across frailty categories, from 38% in robust patients to 55% in severely frail patients (\n                      <jats:italic>p<\/jats:italic>\n                      =\u20090.005).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Among patients aged 75\u2009years and older undergoing\n                      <jats:styled-content style=\"fixed-case\">TAVR<\/jats:styled-content>\n                      , frailty assessed by Rockwood's\n                      <jats:styled-content style=\"fixed-case\">CFS<\/jats:styled-content>\n                      was the most robust geriatric predictor of five\u2010year mortality. These findings support the integration of frailty assessment into long\u2010term prognostic evaluation and highlight the potential value of combined cardiology and geriatric follow\u2010up after\n                      <jats:styled-content style=\"fixed-case\">TAVR<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.70660","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T03:03:59Z","timestamp":1786590239000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Frailty and Five\u2010Year Mortality After\n                    <scp>TAVR<\/scp>\n                    in Patients Aged 75\u2009Years and Older"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3549-1378","authenticated-orcid":false,"given":"J\u00e9r\u00e9mie","family":"Huet","sequence":"first","affiliation":[{"name":"Movement\u2010Interactions\u2010Performance, MIP, UR 4334 Nantes Universit\u00e9, CHU Nantes  Nantes France"},{"name":"Pole de G\u00e9rontologie Clinique Nantes Universit\u00e9, CHU Nantes  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lissa","family":"Sabin","sequence":"additional","affiliation":[{"name":"Pole de G\u00e9rontologie Clinique Nantes Universit\u00e9, CHU Nantes  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Le Tourneau","sequence":"additional","affiliation":[{"name":"CNRS, INSERM, l\u2019institut du thorax Nantes Universit\u00e9, CHU Nantes  Nantes 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