{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T20:28:40Z","timestamp":1786566520772,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["#R01AG070252\u201004S1"],"award-info":[{"award-number":["#R01AG070252\u201004S1"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["#R01AG070252A"],"award-info":[{"award-number":["#R01AG070252A"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Social isolation is increasingly prevalent among older adults and is associated with adverse health outcomes, yet its impact in surgical populations remains poorly defined. Lack of systematic measurement during surgical care has limited large\u2010scale investigation of social isolation and its associations with postoperative outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a prospective validation study of adults \u2265\u200965\u2009years old admitted to inpatient surgical services at an academic medical center to evaluate the accuracy of a semi\u2010automated, rule\u2010based natural language processing (NLP) algorithm for identifying social isolation from routine electronic health record (EHR) clinical notes from index hospitalizations. NLP performance was validated against a 6\u2010item Social Isolation Index administered in\u2010person during hospitalization. The primary outcome was sensitivity of the NLP algorithm for identifying social isolation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 249 enrolled patients (median age, 74\u2009years; 55% female), 55 (22.1%) were classified as socially isolated by the patient\u2010reported reference standard, and the NLP algorithm identified social isolation in 47 patients (18.9%). Sensitivity was 0.84 (95% CI, 0.71\u20130.92); specificity was 0.99 (95% CI, 0.97\u20131.00); positive predictive value was 0.98 (95% CI, 0.89\u20131.00); negative predictive value was 0.96 (95% CI, 0.92\u20130.98); accuracy was 0.96 (95% CI, 0.93\u20130.98); F1 score was 0.90 (95% CI, 0.84\u20130.96).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this prospective validation study of older surgical patients, a semi\u2010automated, rule\u2010based NLP algorithm demonstrated strong performance in identifying social isolation using routine EHR documentation. With further automation and external validation, EHR\u2010based identification of social isolation could complement embedded screening tools in perioperative care strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.70668","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T19:46:05Z","timestamp":1786563965000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development and Validation of a Natural Language Processing Algorithm to Identify Social Isolation in Older Surgical Patients"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0301-7724","authenticated-orcid":false,"given":"Daniel I.","family":"Hoffman","sequence":"first","affiliation":[{"name":"Center for Surgery and Public Health Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Department of Surgery Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sydney","family":"Moore","sequence":"additional","affiliation":[{"name":"Center for Surgery and Public Health Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Sheu","sequence":"additional","affiliation":[{"name":"Center for Surgery and Public Health Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyuan","family":"Ruan","sequence":"additional","affiliation":[{"name":"Center for Surgery and Public Health Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Department of Medicine Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Sciacca","sequence":"additional","affiliation":[{"name":"The Heller School for Social Policy &amp; Management Brandeis University  Waltham Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2317-2628","authenticated-orcid":false,"given":"Masami","family":"Tabata\u2010Kelly","sequence":"additional","affiliation":[{"name":"Center for Surgery and Public Health Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"The Heller School for Social Policy &amp; Management Brandeis University  Waltham Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zara","family":"Cooper","sequence":"additional","affiliation":[{"name":"Center for Surgery and Public Health Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Department of Surgery Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotta","family":"Lindvall","sequence":"additional","affiliation":[{"name":"Department of Medicine Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Supportive Oncology Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Office of the U.S. Surgeon General \u201cOur Epidemic of Loneliness and Isolation: The U.S. Surgeon General's Advisory on the Healing Effects of Social Connection and Community \u201d 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