{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:46:59Z","timestamp":1791103619069,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T00:00:00Z","timestamp":1357516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Human Nutrition Diet"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Untreated glycogen storage disease (<jats:styled-content style=\"fixed-case\">GSD)<\/jats:styled-content>\u20101a patients experience hypoglycaemia and growth retardation. The present study examined the effects of dietary interventions on the maintenance of normoglycaemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical trials were identified from <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content> (January 1980 to November 2011), <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content> (January 1948 to November 2011) and the Cochrane Central Register of Controlled Trials (2011, Issue 4). The intermittent administration of uncooked cornstarch was compared with: (i) continuous nocturnal feeding of dextrose; (ii) modified uncooked cornstarch; and (iii) dextrose and an uncooked cornstarch\u2013dextrose mixture. One author extracted the data, and assessed the trial eligibility and risk of bias. Quality assessment and data extraction were conducted and checked independently.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 41 articles retrieved, five controlled trials (49 participants) were identified with follow\u2010up at 2\u00a0days to 14\u00a0years. Results from three nonrandomised controlled trials comparing uncooked cornstarch with continuous nocturnal feeding of dextrose were pooled in a meta\u2010analysis based on a fixed\u2010effect model. Twenty\u2010six participants (three trials) receiving uncooked cornstarch showed a significant increase in blood glucose concentration: <jats:styled-content style=\"fixed-case\">mean difference (MD)<\/jats:styled-content> 0.62\u00a0mmol\u00a0L<jats:sup>\u22121<\/jats:sup> [95% confidence interval (<jats:styled-content style=\"fixed-case\">CI)<\/jats:styled-content>\u00a0=\u00a00.23\u20131.00] (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002), 21 (two trials) increased serum insulin: <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> 62.37\u00a0pmol\u00a0L<jats:sup>\u22121<\/jats:sup> (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a032.19\u201392.55) (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001) and 22 (three trials) increased plasma total cholesterol: <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> 0.68\u00a0mmol\u00a0L<jats:sup>\u22121<\/jats:sup> (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a00.17\u2013 1.20) (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.01) compared to continuous nocturnal feeding of dextrose. Twenty\u2010eight subjects (three trials) showed decreased plasma lactate after nocturnal feeding: <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> \u20130.42\u00a0mmol\u00a0L<jats:sup>\u22121<\/jats:sup> (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a0\u22120.58 to \u22120.25) (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.00001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Short\u2010 to long\u2010term overnight intermittent administration of uncooked cornstarch prevents nocturnal hypoglycaemia in <jats:styled-content style=\"fixed-case\">GSD<\/jats:styled-content>\u20101a children more effectively than continuous nocturnal feeding of dextrose.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jhn.12030","type":"journal-article","created":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T14:58:55Z","timestamp":1357570735000},"page":"329-339","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Effect of dietary interventions in the maintenance of normoglycaemia in glycogen storage disease type 1a: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"26","author":[{"given":"K. K.","family":"Shah","sequence":"first","affiliation":[{"name":"Diabetes and Nutritional Sciences Division School of Medicine King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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