{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:12:31Z","timestamp":1790262751314,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T00:00:00Z","timestamp":1364947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Human Nutrition Diet"],"published-print":{"date-parts":[[2013,7]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n There is an increasing number of adults with phenylketonuria (\n PKU<\/jats:styled-content>\n ) on a low phenylalanine diet. In the general population, an increasing body mass index (\n BMI<\/jats:styled-content>\n ) in the\n UK<\/jats:styled-content>\n is a major problem with associated co\u2010morbidities. The present study aimed to identify whether patients with diet\u2010treated\n PKU<\/jats:styled-content>\n have obesity rates comparable to those in the general population.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Two hundred and thirty\u2010six\n PKU<\/jats:styled-content>\n subjects (49% male, 51% female), aged >16\u00a0years, who were diagnosed by newborn screening and were receiving a low phenylalanine diet, were identified from seven metabolic centres in the\n UK<\/jats:styled-content>\n . Retrospective data were collated on age, sex,\n BMI<\/jats:styled-content>\n and mean phenylalanine concentration over the previous 12\u00a0months.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Mean (\n SD<\/jats:styled-content>\n ) phenylalanine concentration for all 236 subjects was 789 (311)\u00a0\u03bc\n m<\/jats:sc>\n ; mean (\n SD<\/jats:styled-content>\n )\n BMI<\/jats:styled-content>\n was 26 (5.4)\u00a0kg m\n \u22122<\/jats:sup>\n [males 25 (4.3)\u00a0kg m\n \u22122<\/jats:sup>\n , females 27 (6.2)\u00a0kg m\n \u22122<\/jats:sup>\n ]; mean (\n SD<\/jats:styled-content>\n ) age was 26 (7) years; and 55% had a\n BMI<\/jats:styled-content>\n >\u00a025\u00a0kg m\n \u22122<\/jats:sup>\n . The percentage of subjects with a\n BMI<\/jats:styled-content>\n >25\u00a0kg m\n \u22122<\/jats:sup>\n and >30\u00a0kg m\n \u22122<\/jats:sup>\n , as well as increasing obesity with age, was similar to the\n UK<\/jats:styled-content>\n population. A correlation was observed between increasing\n BMI<\/jats:styled-content>\n and a higher phenylalanine concentration (\n r<\/jats:italic>\n \u00a0=\u00a00.243,\n P\u00a0<\/jats:italic>\n =\u00a00.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The number of overweight and obese patients with diet\u2010treated\n PKU<\/jats:styled-content>\n in the\n UK<\/jats:styled-content>\n is a concern. This could lead to other obesity\u2010related complications increasing the complexity of diet and the cost of their care. There is a need to educate patients with respect to adopting a healthy, low phenylalanine diet and lifestyle to prevent further rises in\n BMI<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jhn.12054","type":"journal-article","created":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T02:52:50Z","timestamp":1364957570000},"page":"1-6","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Body mass index in adult patients with diet\u2010treated phenylketonuria"],"prefix":"10.1111","volume":"26","author":[{"given":"L. V.","family":"Robertson","sequence":"first","affiliation":[{"name":"University Hospitals Birmingham NHS Foundation Trust Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"McStravick","sequence":"additional","affiliation":[{"name":"The Royal Hospitals Metabolic Clinics The Royal Victoria The Royal Hospitals BHSCT Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ripley","sequence":"additional","affiliation":[{"name":"Salford Royal NHS Foundation Trust Salford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Weetch","sequence":"additional","affiliation":[{"name":"Northern General Hospital Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Donald","sequence":"additional","affiliation":[{"name":"Cambridge University Hospitals NHS Foundation Trust Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Adam","sequence":"additional","affiliation":[{"name":"Royal Hospital for Sick Children Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Micciche","sequence":"additional","affiliation":[{"name":"Guy's and St Thomas' NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Boocock","sequence":"additional","affiliation":[{"name":"University Hospitals Birmingham NHS Foundation Trust Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"MacDonald","sequence":"additional","affiliation":[{"name":"Birmingham Children's Hospital NHS Foundation Trust Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2011.05.017"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2011.08.002"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60961-0"},{"key":"e_1_2_8_5_1","volume-title":"Foresight, Tackling Obesities: Future Choices Project Report","author":"Butland B.","year":"2007"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2009.10.007"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2009.10.183"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-010-9247-7"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-010-9253-9"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-007-0549-3"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-007-0436-y"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.68.3.426"},{"key":"e_1_2_8_13_1","first-page":"S49","article-title":"Raised body mass index of adult patients with PKU","volume":"34","author":"Mobayed E.","year":"2011","journal-title":"J. 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