{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T23:10:27Z","timestamp":1696374627543},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,6,20]],"date-time":"2013-06-20T00:00:00Z","timestamp":1371686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Human Nutrition Diet"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Being underweight or overweight and obesity at diagnosis may all worsen prognosis in childhood acute lymphoblastic leukaemia (<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>), although no studies have estimated the prevalence of an unhealthy weight status at diagnosis in large representative samples using contemporary definitions of weight status based on body mass index (<jats:styled-content style=\"fixed-case\">BMI)<\/jats:styled-content> for age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present study comprised a retrospective study that aimed to estimate prevalence of being underweight and overweight and obesity at diagnosis for patients with childhood <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> on three successive <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> treatment trials: <jats:styled-content style=\"fixed-case\">UKALL<\/jats:styled-content> X (1985\u20131990; <jats:italic>n<\/jats:italic>\u00a0=\u00a01033), <jats:styled-content style=\"fixed-case\">UKALL XI<\/jats:styled-content> (1990\u20131997; <jats:italic>n<\/jats:italic>\u00a0=\u00a02031), <jats:styled-content style=\"fixed-case\">UKALL<\/jats:styled-content> 97\/99 (1997\u20132002; <jats:italic>n<\/jats:italic>\u00a0=\u00a0898).The <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> for age was used to define weight status with both <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> 1990 <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> for age reference data and the Cole\u2010International Obesity Task Force (<jats:styled-content style=\"fixed-case\">IOTF<\/jats:styled-content>) definitions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of being underweight was 6% in the most recent trial for which data were available. The prevalence of being overweight and obesity was 35% in the most recent trial when expressed using Cole\u2010<jats:styled-content style=\"fixed-case\">IOTF<\/jats:styled-content> definitions and 41% when expressed relative to <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> 1990 reference data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Even with highly conservative estimates, &gt;40% of all <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> patients with <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> were underweight, overweight or obese at diagnosis in the most recent trial for which <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> data are available (<jats:styled-content style=\"fixed-case\">UKALL<\/jats:styled-content> 97\/99, 1997\u20132002).<\/jats:p><\/jats:sec>","DOI":"10.1111\/jhn.12112","type":"journal-article","created":{"date-parts":[[2013,6,20]],"date-time":"2013-06-20T10:29:48Z","timestamp":1371724188000},"page":"76-79","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prevalence of being underweight and overweight and obesity at diagnosis in <scp>UK<\/scp> patients with childhood acute lymphoblastic leukaemia 1985\u20132002"],"prefix":"10.1111","volume":"27","author":[{"given":"F. K.","family":"Aldhafiri","sequence":"first","affiliation":[{"name":"Developmental Medicine University of Glasgow Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. H.","family":"McColl","sequence":"additional","affiliation":[{"name":"School of Mathematics and Statistics University of Glasgow Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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