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Free radicals, including reactive oxygen and nitrogen species, promote oxidative stress, leading to platelet hyperactivation and the risk of thrombosis. The consumption of antioxidant\/polyphenol rich foods might therefore impart anti\u2010thrombotic and cardiovascular protective effects via their inhibition of platelet hyperactivation or aggregation. Most commonly\u2010used anti\u2010platelet drugs such as aspirin block the cyclooxygenase (COX)\u20101 pathway of platelet activation, similar to the action of antioxidants with respect to neutralising hydrogen peroxide (H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>), with a similar effect on thromboxane production via the <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20101 pathway. Polyphenols also target various additional platelet activation pathways (e.g. by blocking platelet\u2010<jats:styled-content style=\"fixed-case\">ADP<\/jats:styled-content>, collagen receptors); thus alleviating fibrinogen binding to platelet surface (<jats:styled-content style=\"fixed-case\">GPII<\/jats:styled-content>b\u2010<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>a) receptors, reducing further platelet recruitment for aggregation and inhibiting platelet degranulation. 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