{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T06:47:30Z","timestamp":1774853250646,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,6,27]],"date-time":"2014-06-27T00:00:00Z","timestamp":1403827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"University Research Board of the American University of Beirut"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Human Nutrition Diet"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Limited data exist so far on cardiovascular disease biomarkers in patients maintained on a protein\u2010restricted diet for inborn errors of protein metabolism. The present study aimed to analyse plasma cholesterol, lipoproteins, triglycerides and total homocysteine in patients with various inborn errors of protein metabolism in comparison with healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study of cardiovascular disease biomarkers was conducted in a cohort of patients with inborn errors of protein metabolism: nine phenylketonuria, nine urea cycle defect, six branched chain organic acidaemia and two tyrosinaemia type I patients compared to 30 healthy controls. All patients were on a strict natural protein diet for a mean (SD) period of 5.37\u00a0(2.30)\u00a0years (range 2\u20139\u00a0years). Dietary assessment, plasma cholesterol, triglycerides, lipoproteins and total homocysteine levels were obtained.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant differences in blood lipid studies and total homocysteine levels between patients and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results obtained in this pilot study suggest that cardiovascular disease biomarkers are not increased in patients with inborn errors of protein metabolism. This may be explained by the possible protective effect of a mono\u2010 and polyunsaturated fat rich Mediterranean diet. Additional studies with a larger number of patients are needed to confirm this finding.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jhn.12255","type":"journal-article","created":{"date-parts":[[2014,6,27]],"date-time":"2014-06-27T05:47:56Z","timestamp":1403848076000},"page":"344-349","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cardiovascular disease biomarkers in patients with inborn errors of protein metabolism: a pilot study"],"prefix":"10.1111","volume":"28","author":[{"given":"P. E.","family":"Karam","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine American University of Beirut Medical Center Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. N.","family":"Majdalani","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine American University of Beirut Medical Center Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. T.","family":"Daher","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine American University of Beirut Medical Center Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Barhoumi","sequence":"additional","affiliation":[{"name":"Department of Nutrition American University of Beirut Medical Center Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Yazbeck","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine American University of Beirut Medical Center Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1054\/plef.2001.0249"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.88.7.582"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-006-0182-6"},{"key":"e_1_2_8_5_1","first-page":"160","article-title":"Lipid profile and nutritional intake in children and adolescents with type 1 diabetes improve after a structured dietician training to a Mediterranean\u2010style diet","volume":"35","author":"Cadario F.","year":"2012","journal-title":"J. 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