{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T00:11:31Z","timestamp":1793751091350,"version":"4.6.1"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,9,25]],"date-time":"2014-09-25T00:00:00Z","timestamp":1411603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Human Nutrition Diet"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Protein\u2010energy wasting (<jats:styled-content style=\"fixed-case\">PEW<\/jats:styled-content>) is a highly prevalent condition in haemodialysis patients (<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>). The potential usefulness of nutritional\u2010inflammatory markers in the diagnosis of <jats:styled-content style=\"fixed-case\">PEW<\/jats:styled-content> in chronic kidney disease has not been established completely. We hypothesised that a combination of serum albumin, percentage of mid\u2010arm muscle circumference and standard body weight comprises a better discriminator than either single marker of nutritional status in <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study was performed in 80 <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> patients. Patients were categorised in two groups: well\u2010nourished and <jats:styled-content style=\"fixed-case\">PEW<\/jats:styled-content>. Logistic regression analysis was applied to corroborate the reliability of the three markers of <jats:styled-content style=\"fixed-case\">PEW<\/jats:styled-content> with all the nutritional\u2010inflammatory markers analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PEW<\/jats:styled-content> was identified in 52.5% of <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> patients. Compared with the well\u2010nourished patients, <jats:styled-content style=\"fixed-case\">PEW<\/jats:styled-content> patients had lower <jats:styled-content style=\"fixed-case\">body mass index<\/jats:styled-content>, serum pre\u2010albumin and body cell mass (all <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001) and higher C\u2010reactive protein (s\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>) (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01). Logistic regression analyses showed that the combination of the three criteria were significantly related with s\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> &gt;1\u00a0mg <jats:styled-content style=\"fixed-case\">dL<\/jats:styled-content><jats:sup>\u22121<\/jats:sup>, phase angle &lt;4\u00b0, and serum pre\u2010albumin &lt;30\u00a0mg <jats:styled-content style=\"fixed-case\">dL<\/jats:styled-content><jats:sup>\u22121<\/jats:sup> (all <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05). Other indicators, such as lymphocytes &lt;20% and Charlson comorbidity index, were significantly involved (both <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01). A <jats:styled-content style=\"fixed-case\">receiver operating characteristic curve<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">area under the curve<\/jats:styled-content>) of 0.86 (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001) was found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The combined utilisation of serum albumin, percentage of mid\u2010arm muscle circumference and standard body weight as <jats:styled-content style=\"fixed-case\">PEW<\/jats:styled-content> markers appears to be useful for nutritional\u2010inflammatory status assessment and adds predictive value to the traditional indicators. Larger studies are needed to achieve the reliability of these predictor combinations and their cut\u2010off values in <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> patients and other populations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jhn.12276","type":"journal-article","created":{"date-parts":[[2014,9,25]],"date-time":"2014-09-25T07:22:48Z","timestamp":1411629768000},"page":"38-47","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Predictors of protein\u2010energy wasting in haemodialysis patients: a cross\u2010sectional study"],"prefix":"10.1111","volume":"29","author":[{"given":"M.","family":"Ruperto","sequence":"first","affiliation":[{"name":"Departamento de Nutrici\u00f3n Humana y Diet\u00e9tica Facultad de Ciencias de la Salud Universidad Alfonso X el Sabio Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. J.","family":"S\u00e1nchez\u2010Muniz","sequence":"additional","affiliation":[{"name":"Departamento de Nutrici\u00f3n y Bromatolog\u00eda I (Nutrici\u00f3n) Facultad de Farmacia Universidad Complutense de Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Barril","sequence":"additional","affiliation":[{"name":"Servicio de Nefrolog\u00eda Hospital Universitario La Princesa Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,25]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"407","article-title":"Valoraci\u00f3n de los par\u00e1metros antropom\u00e9tricos en nuestra poblaci\u00f3n","volume":"78","author":"Alastrue A.","year":"1982","journal-title":"Med. Clin."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jrn.2005.10.003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2004.08.023"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/82.4.909"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jrn.2005.01.004"},{"key":"e_1_2_7_7_1","first-page":"197","article-title":"Body mass index and cardiovascular risk factors and biomarkers in hemodialysis patients","volume":"21","author":"Bossola M.","year":"2008","journal-title":"J. Nephrol."},{"key":"e_1_2_7_8_1","volume-title":"The Tietz Textbook of Clinical Chemistry","author":"Burtis C.A.","year":"1999"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/85.3.695"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2008.04.007"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1051-2276(97)90020-0"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1997.493"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/jren.2003.50003"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032804"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn167"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2009.01.009"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2008.06.013"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002585"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.31.83"},{"key":"e_1_2_7_20_1","first-page":"495","article-title":"Prevalence of protein\u2010energy wasting syndrome and its association with mortality in hemodialysis patients in a centre in Spain","volume":"33","author":"Gracia\u2010Iguacel C.","year":"2013","journal-title":"Nefrologia"},{"key":"e_1_2_7_21_1","volume-title":"Clinical chemistry: Principles and Techniques","author":"Henry R.J.","year":"1974"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2009.07.009"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/jren.2002.35295"},{"key":"e_1_2_7_24_1","first-page":"S1","article-title":"Clinical practice guidelines for nutrition in chronic renal failure","volume":"35","author":"K\/DOQI, National Kidney Foundation","year":"2000","journal-title":"Am. J. Kidney Dis."},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(03)00654-1"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00803.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1053\/jren.2003.50005"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1602516"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00172.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00721.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/14.9.2165"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2008.27390"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.5414\/CNP63022"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm453"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jrn.2009.10.002"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn053"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2001.29256"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(03)00532-8"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02080310"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jrn.2010.01.001"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2008.25906"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-011-0085-9"},{"key":"e_1_2_7_43_1","first-page":"3","article-title":"The phase angle is a useful diagnostic parameter of malnutrition\u2010inflammation syndrome in hemodialysis patients prevalent","volume":"25","author":"Ruperto M.","year":"2010","journal-title":"Nutr. Hosp."},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq497"},{"key":"e_1_2_7_45_1","first-page":"1575","article-title":"Malnutrition, and anthropometric and biochemical abnormalities in end\u2010stage renal disease patients","volume":"28","author":"Tayyem R.F.","year":"2007","journal-title":"Saudi Med. J."},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg269"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/57.5.M326"},{"key":"e_1_2_7_48_1","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1093\/ajcn\/39.4.547","article-title":"Nutritional status and lymphocyte function in maintenance hemodialysis patients","volume":"39","author":"Wolfson M.","year":"1984","journal-title":"Am. J. Clin. Nutr."},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00564-3"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.5301\/jn.5000169"}],"container-title":["Journal of Human Nutrition and Dietetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjhn.12276","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjhn.12276","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jhn.12276","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T07:58:49Z","timestamp":1696233529000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jhn.12276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,25]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1111\/jhn.12276"],"URL":"https:\/\/doi.org\/10.1111\/jhn.12276","archive":["Portico"],"relation":{},"ISSN":["0952-3871","1365-277X"],"issn-type":[{"value":"0952-3871","type":"print"},{"value":"1365-277X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,25]]},"assertion":[{"value":"2014-09-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}