{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:12:40Z","timestamp":1787015560337,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,10,29]],"date-time":"2015-10-29T00:00:00Z","timestamp":1446076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010887","name":"Vitaflo","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010887","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Nutricia"},{"name":"Merck Serono"},{"name":"Birmingham Children's Hospital Research Foundation"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Human Nutrition Diet"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      In phenylketonuria (\n                      <jats:styled-content style=\"fixed-case\">PKU<\/jats:styled-content>\n                      ), little is known about the effect of bitter\u2010tasting phenylalanine\u2010free\n                      <jats:sc>l<\/jats:sc>\n                      \u2010amino acid exposure on taste preference development. The present prospective study aimed to determine the flavour preferences of children with\n                      <jats:styled-content style=\"fixed-case\">PKU<\/jats:styled-content>\n                      versus healthy control children.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010five children with\n                      <jats:styled-content style=\"fixed-case\">PKU<\/jats:styled-content>\n                      and 35 age\/gender\u2010matched controls, aged 4\u201313\u00a0years, tasted 10 blinded puree foods in random order. They were rated using a seven\u2010point pictorial hedonic scale (super yummy to super yucky) and ranked in preferential order. Caregivers completed a neophobia and food frequency questionnaire on behalf of their children.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both\n                      <jats:styled-content style=\"fixed-case\">PKU<\/jats:styled-content>\n                      and control groups rated sweet foods higher than savoury, bitter and sour foods. However, control children ranked fruits as a group higher than\n                      <jats:styled-content style=\"fixed-case\">PKU<\/jats:styled-content>\n                      children (mean 3.7 versus 4.6;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.03), whereas\n                      <jats:styled-content style=\"fixed-case\">PKU<\/jats:styled-content>\n                      children ranked vegetables as a group higher than controls (mean 5.6 versus 6.3;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.05). Children with\n                      <jats:styled-content style=\"fixed-case\">PKU<\/jats:styled-content>\n                      had more neophobia and were untrusting\/fearful of new foods.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Although there was some evidence to suggest that children with\n                      <jats:styled-content style=\"fixed-case\">PKU<\/jats:styled-content>\n                      aged \u22654\u00a0years prefer savoury foods (vegetables) more than control children, they did not prefer bitter\u2010tasting foods, and so early and persistent administration of bitter\u2010tasting\n                      <jats:sc>l<\/jats:sc>\n                      \u2010amino acids was not associated with apparent taste imprinting. Neophobia appears to play significant part in food refusal in\n                      <jats:styled-content style=\"fixed-case\">PKU<\/jats:styled-content>\n                      , perhaps more so than taste preferences.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jhn.12346","type":"journal-article","created":{"date-parts":[[2015,10,29]],"date-time":"2015-10-29T07:32:50Z","timestamp":1446103970000},"page":"427-433","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Food acceptance and neophobia in children with phenylketonuria: a prospective controlled study"],"prefix":"10.1111","volume":"29","author":[{"given":"S.","family":"Evans","sequence":"first","affiliation":[{"name":"Dietetic Department, Birmingham Children's Hospital Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Daly","sequence":"additional","affiliation":[{"name":"Dietetic 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