{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T17:20:16Z","timestamp":1769275216375,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,3,6]],"date-time":"2016-03-06T00:00:00Z","timestamp":1457222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Food and Drug Safety in 2012","award":["12161MFDS118"],"award-info":[{"award-number":["12161MFDS118"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Human Nutrition Diet"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Previous studies of the health effects of low\u2010fat milk or dairy consumption on the metabolic syndrome have yielded inconsistent results. The present study aimed to investigate the effects of low\u2010fat milk consumption on traits associated with the metabolic syndrome, as well as inflammatory and atherogenic biomarkers, in Korean adults with the metabolic syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Overweight Koreans with the metabolic syndrome (<jats:italic>n<\/jats:italic> = 58) were recruited and randomly assigned to either the low\u2010fat milk or control group. The low\u2010fat milk group was instructed to consume two packs of low\u2010fat milk per day (200 <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> twice daily) for 6 weeks, and the control group was instructed to maintain their habitual diet. Clinical investigations were conducted during the screening visit, on study day 0, and after 6 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant differences in changes in body mass index, blood pressure, lipid profile and adiponectin levels, as well as levels of inflammatory markers, oxidative stress markers and atherogenic markers, were found between the low\u2010fat milk and control groups. However, compared to the controls, significant favourable decreases in serum soluble vascular adhesion molecule\u20101 and endothelin\u20101 levels were found in the 12 subjects with high blood pressure and in the 18 subjects with hypertriglyceridaemia in the low\u2010fat milk group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present study did not demonstrate an overall beneficial effect of low\u2010fat milk consumption in subjects with the metabolic syndrome. However, low\u2010fat milk consumption may have a favourable effect on atherogenic markers in subjects with high blood pressure or hypertriglyceridaemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jhn.12349","type":"journal-article","created":{"date-parts":[[2016,3,6]],"date-time":"2016-03-06T11:50:42Z","timestamp":1457265042000},"page":"477-486","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Effects of low\u2010fat milk consumption on metabolic and atherogenic biomarkers in Korean adults with the metabolic syndrome: a randomised controlled trial"],"prefix":"10.1111","volume":"29","author":[{"given":"Y. J.","family":"Lee","sequence":"first","affiliation":[{"name":"Nutrition and Functional Food Research Team National Institute of Food and Drug Safety Evaluation Chungcheongbuk\u2010do Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A.","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism Korea University Ansan Hospital College of Medicine Korea University Ansan\u2010si Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Yoon","sequence":"additional","affiliation":[{"name":"Nutrition and Functional Food Research Team National Institute of Food and Drug Safety Evaluation Chungcheongbuk\u2010do Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Seo","sequence":"additional","affiliation":[{"name":"Nutrition and Functional Food Research Team National Institute of Food and Drug Safety Evaluation Chungcheongbuk\u2010do Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. H.","family":"Lee","sequence":"additional","affiliation":[{"name":"Nutrition and Functional Food Research Team National Institute of Food and Drug Safety Evaluation Chungcheongbuk\u2010do Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Im","sequence":"additional","affiliation":[{"name":"Nutrition and Functional Food Research Team National Institute of Food and Drug Safety Evaluation Chungcheongbuk\u2010do Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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