{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:50:24Z","timestamp":1790196624253,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T00:00:00Z","timestamp":1487203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000589","name":"Chief Scientist Office","doi-asserted-by":"publisher","award":["CZG\/2\/558"],"award-info":[{"award-number":["CZG\/2\/558"]}],"id":[{"id":"10.13039\/501100000589","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Human Nutrition Diet"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Observational studies suggest a potentially protective role of the Mediterranean diet (\n                      <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>\n                      ) in allergic diseases, including asthma. Large scale randomised controlled trials (\n                      <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>\n                      s) are needed to test the hypothesised allergy\u2010prevention benefits of a\n                      <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>\n                      during pregnancy. The present two\u2010arm pilot\n                      <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>\n                      in pregnant women at high\u2010risk of having a child who would develop allergic disease investigated maternal recruitment, retention and acceptability of an\n                      <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>\n                      dietary intervention in the\n                      <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content>\n                      . The trial also assessed the effect of the intervention on\n                      <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>\n                      adherence scores at 12 and at 24\u00a0weeks post\u2010randomisation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Thirty women were recruited at around 12\u00a0weeks of gestation. Retention was high (28 out of 30; 93%). The intervention was acceptable to participants. Mean (SD) adherence to the\n                      <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>\n                      at baseline was 12.4\u00a0(2.9) in the intervention arm (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a014) and 13.0\u00a0(1.9) in the control arm (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a016), where 24 represents maximal adherence. There was a favourable short\u2010term change in\n                      <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>\n                      score: the adjusted mean difference (intervention\u00a0\u2013\u00a0control) in the change in\n                      <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>\n                      score from baseline to 12\u00a0weeks post\u2010randomisation was 2.4 (95% confidence interval\u00a0=\u00a00.6\u20134.2,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.012).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The trial provides important insights into recruitment, retention and sustaining the dietary intervention, which will be used in the design of a large\n                      <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jhn.12469","type":"journal-article","created":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T21:48:11Z","timestamp":1487281691000},"page":"604-614","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["A pilot\n                    <scp>randomised controlled trial<\/scp>\n                    investigating a Mediterranean diet intervention in pregnant women for the primary prevention of allergic diseases in infants"],"prefix":"10.1111","volume":"30","author":[{"given":"D. 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