{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T01:05:15Z","timestamp":1768525515784,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T00:00:00Z","timestamp":1488758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Human Nutrition Diet"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Gestational diabetes mellitus (<jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content>) is an increasing prevalent health risk in pregnant women. Epigallocatechin 3\u2010gallate (<jats:styled-content style=\"fixed-case\">EGCG<\/jats:styled-content>) is known to benefit the insulin secretory machinery. We aimed to investigate the effect of daily dietary <jats:styled-content style=\"fixed-case\">EGCG<\/jats:styled-content> supplementation on both the maternal and neonatal treatment outcomes in <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content>\u2010affected pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 472 pregnant women during their third trimester of pregnancy were diagnosed with <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content> and subsequently enrolled into this trial. After exclusion, 404 patients were randomly assigned into <jats:styled-content style=\"fixed-case\">EGCG<\/jats:styled-content> and placebo study groups and subsequently administered either 500 mg of <jats:styled-content style=\"fixed-case\">EGCG<\/jats:styled-content> or placebo, respectively, on a daily basis until full term. The daily nutritional intake of all patients was monitored throughout the study. Maternal diabetic parameters at baseline and full term, including metabolism of glucose and insulin, as well as neonatal symptoms at birth, including birth weight, macrosomia, hypoglycaemia, respiratory distress and Apgar scores, were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 176 and 150 patients from the <jats:styled-content style=\"fixed-case\">EGCG<\/jats:styled-content> and placebo study groups, respectively, completed the trial. Patients from the <jats:styled-content style=\"fixed-case\">EGCG<\/jats:styled-content> group displayed significantly improved maternal diabetic parameters, and fewer cases of neonatal complications, compared to the placebo group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Daily dietary <jats:styled-content style=\"fixed-case\">EGCG<\/jats:styled-content> supplement improves both maternal and neonatal treatment outcomes of <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jhn.12470","type":"journal-article","created":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T02:33:14Z","timestamp":1488853994000},"page":"753-758","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Dietary epigallocatechin 3\u2010gallate supplement improves maternal and neonatal treatment outcome of gestational diabetes mellitus: a double\u2010blind 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