{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:40:57Z","timestamp":1792176057206,"version":"4.4.0"},"reference-count":52,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T00:00:00Z","timestamp":1519257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology , Ministry of Science and Technology","doi-asserted-by":"publisher","award":["BIOCHILD [GAP 0089]"],"award-info":[{"award-number":["BIOCHILD [GAP 0089]"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology , Ministry of Science and Technology","doi-asserted-by":"publisher","award":["GLUE [N 1292]"],"award-info":[{"award-number":["GLUE [N 1292]"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Human Nutrition Diet"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Micronutrient deficiency is a global health burden, especially among developing countries. The present cross\u2010sectional study aimed to determine the prevalence of vitamin B<jats:sub>12<\/jats:sub> deficiency in healthy Indian school\u2010going adolescents, based on area of residence, sex and body mass index (<jats:styled-content style=\"fixed-case\">BMI)<\/jats:styled-content>. Furthermore, the relationship of serum B<jats:sub>12<\/jats:sub> concentration with dietary vitamin B<jats:sub>12<\/jats:sub> intake and anthropometric indices was assessed among adolescents from rural and urban India.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 2403 school\u2010going adolescents (11\u201317\u00a0years) from National Capital Region and rural areas of Haryana, India were selected. Serum B<jats:sub>12<\/jats:sub> concentrations were estimated using an electrochemiluminescence immunoassay. Dietary assessments were conducted on 65% of total participants (<jats:italic>n<\/jats:italic>\u00a0=\u00a01556) by two 24\u2010h diet recalls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of vitamin B<jats:sub>12<\/jats:sub> deficiency in the total study population was 32.4% (rural: 43.9% versus urban: 30.1%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001; male: 34.4% versus female: 31.0%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05; normal weight: 28.1%, versus overweight: 39.8%, versus obese: 51.2%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). More than half (51.2%) of obese adolescents were vitamin B<jats:sub>12<\/jats:sub> deficient. On multiple linear regression analysis, serum B<jats:sub>12<\/jats:sub> in rural adolescents was associated with age (\u03b2\u00a0=\u00a0\u22120.12, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Among urban adolescents, serum B<jats:sub>12<\/jats:sub> was associated with <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> (\u03b2\u00a0=\u00a0\u22120.08, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) and adjusted dietary vitamin B<jats:sub>12<\/jats:sub> intake (\u03b2\u00a0=\u00a00.14, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Serum vitamin B<jats:sub>12<\/jats:sub> levels were found to be lower in rural females (\u03b2\u00a0=\u00a0\u22120.12, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.030) and urban males (\u03b2: 0.11, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) compared to their respective contemporaries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Vitamin B<jats:sub>12<\/jats:sub> deficiency was higher among rural school\u2010going adolescents. Boys had a higher B<jats:sub>12<\/jats:sub> deficiency than girls. Inverse associations of serum B<jats:sub>12<\/jats:sub> with adiposity indices were observed. Serum B<jats:sub>12<\/jats:sub> levels were positively associated with dietary vitamin B<jats:sub>12<\/jats:sub> intake.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jhn.12541","type":"journal-article","created":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T07:22:43Z","timestamp":1519284163000},"page":"513-522","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Prevalence of vitamin B<sub>12<\/sub> deficiency in healthy Indian school\u2010going adolescents from rural and urban localities and its relationship with various anthropometric indices: a cross\u2010sectional study"],"prefix":"10.1111","volume":"31","author":[{"given":"S.","family":"Chakraborty","sequence":"first","affiliation":[{"name":"Genomics and Molecular Medicine Unit CSIR\u2010Institute of Genomics and Integrative Biology New Delhi India"},{"name":"Academy of Scientific and Innovative Research CSIR\u2010Institute of Genomics and Integrative Biology New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Chopra","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition Lady Irwin College University of Delhi New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Mani","sequence":"additional","affiliation":[{"name":"Department of Biostatistics All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. K.","family":"Giri","sequence":"additional","affiliation":[{"name":"Genomics and Molecular Medicine Unit CSIR\u2010Institute of Genomics and Integrative Biology New Delhi India"},{"name":"Academy of Scientific and Innovative Research CSIR\u2010Institute of Genomics and Integrative Biology New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Genomics and Molecular Medicine Unit CSIR\u2010Institute of Genomics and Integrative Biology New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. S.","family":"Sahni","sequence":"additional","affiliation":[{"name":"School of Computational and Integrative Sciences Jawaharlal Nehru University New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Siddhu","sequence":"additional","affiliation":[{"name":"Department of Home Science Lady Irwin College University of Delhi New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Tandon","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5268-8482","authenticated-orcid":false,"given":"D.","family":"Bharadwaj","sequence":"additional","affiliation":[{"name":"Genomics and Molecular Medicine Unit CSIR\u2010Institute of Genomics and Integrative Biology New Delhi India"},{"name":"Academy of Scientific and Innovative Research CSIR\u2010Institute of Genomics and Integrative Biology New Delhi India"},{"name":"Systems Genomics Laboratory School of Biotechnology Jawaharlal Nehru University New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.115.008201"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/48.3.852"},{"key":"e_1_2_8_4_1","first-page":"979","article-title":"Vitamin B12 deficiency","volume":"67","author":"Oh R","year":"2003","journal-title":"Am Fam Physician"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/15648265080292S117"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.032268"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665114001554"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/15648265080292S107"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140840"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-750X(99)00048-0"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8709.2007.00086.x"},{"key":"e_1_2_8_12_1","first-page":"1","article-title":"Low holo\u2010transcobalamin levels are prevalent in vegetarians and is associated with coronary artery disease in Indian population","volume":"5804","author":"Basak T","year":"2016","journal-title":"Biomarkers"},{"key":"e_1_2_8_13_1","unstructured":"World Health Organization. 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