{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:52:16Z","timestamp":1790034736205,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,7,22]],"date-time":"2018-07-22T00:00:00Z","timestamp":1532217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Human Nutrition Diet"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with oesophago\u2010gastric (<jats:styled-content style=\"fixed-case\">OG<\/jats:styled-content>) cancer may be at risk of malnutrition, troublesome gastrointestinal symptoms (<jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>) and reduced dietary intake in view of the tumour location and multimodality curative treatment approach. Longitudinal research is lacking. The present study aimed to assess (i) nutritional status and how it evolved over the first year; (ii) the association between nutritional status scores and <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> symptom scores; and (iii) the nutrient and food group intake pattern.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective, observational study of patients with an <jats:styled-content style=\"fixed-case\">OG<\/jats:styled-content> lesion planned for radical treatment, with assessment at diagnosis, 3 months and 12 months after the start of treatment. Nutritional assessment was performed using the Patient\u2010Generated Subjective Global Assessment, <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> symptoms measured using the modified Gastrointestinal Symptom Rating Scale and dietary intake assessed using a semi\u2010quantitative food frequency approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty patients (61 males, 19 females; aged 46\u201389\u00a0years) were recruited. At baseline, 3 (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>68) and 12\u00a0months (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>57), 61%, 62% and 60%, respectively, were moderately\/severely malnourished. Higher symptom burden was associated with poorer nutritional status at baseline (<jats:italic>r\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.55, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001), 3 months (<jats:italic>r\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.51, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001) and 12 months (<jats:italic>r\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.42, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.001). At each respective time point, 37%, 38% and 42% were meeting their estimated average requirement for energy. No change in mean (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) intake of energy, fibre, nutrient and food groups was observed over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">OG<\/jats:styled-content> cancer have progressive weight loss, with malnutrition present over the majority of the 12\u2010month study period. Optimising nutritional status and symptom management throughout the treatment pathway should be a clinical priority.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jhn.12588","type":"journal-article","created":{"date-parts":[[2018,7,23]],"date-time":"2018-07-23T02:48:47Z","timestamp":1532314127000},"page":"785-792","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Nutritional status, the development and persistence of malnutrition and dietary intake in oesophago\u2010gastric cancer: a longitudinal cohort study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8707-4699","authenticated-orcid":false,"given":"E. 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