{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T23:02:44Z","timestamp":1787871764549,"version":"build-2784847793"},"reference-count":64,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T00:00:00Z","timestamp":1534982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006518","name":"University of Nebraska Medical Center","doi-asserted-by":"publisher","award":["UNHB0008"],"award-info":[{"award-number":["UNHB0008"]}],"id":[{"id":"10.13039\/100006518","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Human Nutrition Diet"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Individual variations of obesity\u2010related traits can be a consequence of dietary influence on gene variants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study aimed to evaluate (i) the effect of <jats:italic><jats:styled-content style=\"fixed-case\">FTO<\/jats:styled-content><\/jats:italic> rs9930506 on obesity and related parameters and (ii) the influence of diet on the above association in Malaysian adults. In total, 79 obese and 99 nonobese Malaysian adults were recruited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In comparison with Chinese and Malays, Indians had significantly higher waist circumference (<jats:italic>P<\/jats:italic> \u2264 0.001 and <jats:italic>P<\/jats:italic> = 0.016), waist\u2013hip ratio (<jats:italic>P<\/jats:italic> = 0.001 and <jats:italic>P<\/jats:italic> &lt; 0.001), body fat percentage (<jats:italic>P<\/jats:italic> = 0.001 and <jats:italic>P<\/jats:italic> = 0.042), fasting insulin (<jats:italic>P<\/jats:italic> = 0.001 and <jats:italic>P<\/jats:italic> = 0.001), <jats:styled-content style=\"fixed-case\">homeostatic model assessment\u2010insulin resistance<\/jats:styled-content> (<jats:italic>P<\/jats:italic> = 0.001 and <jats:italic>P<\/jats:italic> = 0.001) and lower <jats:styled-content style=\"fixed-case\">high\u2010density lipoprotein<\/jats:styled-content>\u2010cholesterol levels (<jats:italic>P<\/jats:italic> &lt; 0.001 and <jats:italic>P<\/jats:italic> &lt; 0.001), respectively. Indians consumed significantly lower dietary cholesterol (<jats:italic>P<\/jats:italic> = 0.002), percentage energy from protein (<jats:italic>P<\/jats:italic> &lt; 0.001) and higher fibre (<jats:italic>P<\/jats:italic> = 0.006) compared to the other two groups. Malaysian Indians expressed the highest risk allele frequency (G) of <jats:italic><jats:styled-content style=\"fixed-case\">FTO<\/jats:styled-content><\/jats:italic> rs9930506 compared to the Malays and the Chinese (<jats:italic>P<\/jats:italic> &lt; 0.001).<\/jats:p><jats:p>No significant association was found between <jats:italic><jats:styled-content style=\"fixed-case\">FTO<\/jats:styled-content><\/jats:italic> rs9930506 and obesity (dominant model). Risk allele carriers (G) consumed significantly lower vitamin E (<jats:italic>P<\/jats:italic> = 0.020) and had a higher fibre intake (<jats:italic>P<\/jats:italic> = 0.034) compared to the noncarriers (A). Gene\u2013diet interaction analysis revealed that risk allele carriers (G) had lower high sensitivity C\u2010reactive protein (hsCRP) levels with higher energy from protein (\u226514% day<jats:sup>\u22121<\/jats:sup>; <jats:italic>P<\/jats:italic> = 0.049) and higher vitamin E (\u22655.4 mg day<jats:sup>\u22121<\/jats:sup>; <jats:italic>P<\/jats:italic> = 0.038).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The presence of the risk allele (G) of <jats:italic><jats:styled-content style=\"fixed-case\">FTO<\/jats:styled-content><\/jats:italic> rs9930506 was not associated with an increased risk of obesity. Malaysian Indians had a significantly higher frequency of the risk allele (G). Indian participants expressed higher atherogenic phenotypes compared to Chinese and Malays. <jats:italic><jats:styled-content style=\"fixed-case\">FTO<\/jats:styled-content><\/jats:italic> rs9930506 may interact with dietary protein and vitamin E and modulate hs<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> levels.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jhn.12593","type":"journal-article","created":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T03:15:09Z","timestamp":1535080509000},"page":"758-772","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effect of <i><scp>FTO<\/scp><\/i> rs9930506 on obesity and interaction of the gene variants with dietary protein and vitamin E on C\u2010reactive protein levels in multi\u2010ethnic Malaysian adults"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7045-1550","authenticated-orcid":false,"given":"S. R.","family":"Mitra","sequence":"first","affiliation":[{"name":"School of Biosciences Faculty of Science University of Nottingham Malaysia Campus Semenyih Selangor Darul Ehsan Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Y.","family":"Tan","sequence":"additional","affiliation":[{"name":"School of Biosciences Faculty of Science University of Nottingham Malaysia Campus Semenyih Selangor Darul Ehsan Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Amini","sequence":"additional","affiliation":[{"name":"School of Healthy Aging, Medical Aesthetics &amp; Regenerative Medicine UCSI University Kuala Lumpur Wilayah Persekutuan Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,23]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"1","article-title":"Global, regional, and national prevalence of overweight and obesity in children and adults during 1980\u20102013: a systematic analysis for the Global Burden of Disease Study","volume":"6736","author":"Ng M","year":"2013","journal-title":"Lancet"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpmed.2014.11.003"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.126532"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2012.06.056"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2014.11.005"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2016(04)11"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802808"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18040787"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1151710"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng2048"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2007.10.011"},{"key":"e_1_2_9_13_1","first-page":"232","article-title":"The study of the rs9939609 FTO gene polymorphism in association with obesity and the management of obesity in a Romanian cohort","volume":"8","author":"Ri U","year":"2015","journal-title":"J Med Life"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147904"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2010.71"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2011.12.007"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-017-0372-6"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08-0214"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.108.822320"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2012007500134"},{"key":"e_1_2_9_21_1","first-page":"365","article-title":"Association of fat mass and obesity\u2010associated (FTO) gene Rs9939609 variant with obesity among multi\u2010ethnic malaysians in kampar, perak","volume":"42","author":"Chey WW","year":"2013","journal-title":"Sains Malaysiana"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/872176"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-5916.182617"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)15268-3"},{"key":"e_1_2_9_25_1","first-page":"8","volume-title":"Waist Circumference and Waist\u2010Hip Ratio Report of a WHO Expert Consultation","author":"WHO","year":"2008"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000154900.76284.F6"},{"key":"e_1_2_9_27_1","volume-title":"Nutritional Epidemiology","author":"Baranowski T","year":"2013"},{"key":"e_1_2_9_28_1","first-page":"1","article-title":"Development, validity and reproducibility of a food frequency questionnaire in pregnancy for the Universiti Sains Malaysia birth cohort study","volume":"17","author":"Loy SL","year":"2011","journal-title":"Malays J Nutr"},{"key":"e_1_2_9_29_1","volume-title":"Atlas of Food Exchanges & Portion Sizes","author":"Suzana S","year":"2009"},{"key":"e_1_2_9_30_1","volume-title":"Nutrient Composition of Malaysian Foods","author":"Tee ES","year":"1997"},{"key":"e_1_2_9_31_1","first-page":"583","article-title":"Critical evaluation of energy intake data using fundamental principles of energy physiology: 2. 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